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Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity

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Author(s)
Kyung Jin WooYong-Jin JeongHiroyasu InoueJong-Wook ParkTaeg Kyu Kwon
Keimyung Author(s)
Park, Jong WookKwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
FEBS Lett
Issued Date
2005
Volume
579
Issue
3
Abstract
Chrysin is a natural, biologically active compound extracted
from many plants, honey and propolis. It possesses
potent anti-inflammation, anti-cancer and anti-oxidation properties.
The mechanism by which chrysin suppresses COX-2 expression
remains poorly understood. In the present report, we
investigated the effect of chrysin on the expression of COX-2
in lipopolysaccharide (LPS)-activated Raw 264.7 cells. Chrysin
significantly suppressed the LPS-induced COX-2 protein and
mRNA expression in a dose-dependent manner. The ability of
chrysin to suppress the expression of the COX-2 was investigated
using luciferase reporters controlled by various cis-elements
in COX-2 promoter region. Mutational analysis and
electrophoretic mobility shift assay verified that nuclear factor
for IL-6 was identified as responsible for the chrysin-mediated
COX-2 downregulation. These results will provide new insights
into the anti-inflammatory and anti-carcinogenic properties of
chrysin.
2005 Federation of European Biochemical Societies. Published
by Elsevier B.V. All rights reserved.
Keimyung Author(s)(Kor)
박종욱
권택규
Publisher
School of Medicine
Citation
Kyung Jin Woo et al. (2005). Chrysin suppresses lipopolysaccharide-induced
cyclooxygenase-2 expression through the inhibition of nuclear factor
for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett, 579(3), 705–711. doi: 10.1016/j.febslet.2004.12.048
Type
Article
ISSN
0014-5793
Source
https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2004.12.048
DOI
10.1016/j.febslet.2004.12.048
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35736
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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