계명대학교 의학도서관 Repository

Global gene expression patterns and induction of innate immune response in human laryngeal epithelial cells in response to Acinetobacter baumannii outer membrane protein A

Metadata Downloads
Author(s)
Soon Ae KimSung Min YooSung Hee HyunChul Hee ChoiSo Young YangHwa Jung KimByeong Churl JangSeong Il SuhJe Chul Lee
Keimyung Author(s)
Jang, Byeong ChurlSuh, Seong Il
Department
Dept. of Molecular Medicine (분자의학)
Dept. of Microbiology (미생물학)
Institute for Medical Science (의과학연구소)
Journal Title
FEMS Immunology and Medical Microbiology
Issued Date
2008
Volume
54
Issue
1
Abstract
The outer membrane protein A of Acinetobacter baumannii (AbOmpA) is an
important pathogen-associated molecular pattern that induces host cell death. We
determined the gene expression profiles of human laryngeal epithelial HEp-2 cells
in response to the sublethal concentration of recombinant AbOmpA (rAbOmpA)
and investigated the molecular mechanisms by which rAbOmpA induces an innate
immune response. The microarray analysis showed that rAbOmpA sequentially
regulated a relatively small set of genes, including those associated with signal
transductions and molecules involved in immune response. Among the differentially
expressed genes involved in innate immune responses, the surface expression
of Toll-like receptor 2 and the production of inducible nitric oxide synthase
(iNOS) were prominently observed. However, rAbOmpA did not induce the
production of proinflammatory cytokines and chemokines. rAbOmpA activated
c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase mitogenactivated
protein kinases (MAPKs). Inhibition of JNK MAPK suppressed iNOS
production in the rAbOmpA-treated HEp-2 cells. These results suggest that
interaction of laryngeal epithelial cells with AbOmpA has a significant impact on
the induction of innate immunity during the early stages of A. baumannii
infection.
Keimyung Author(s)(Kor)
장병철
서성일
Publisher
School of Medicine
Citation
Soon Ae Kim et al. (2008). Global gene expression patterns and induction of innate immune
response in human laryngeal epithelial cells in response to
Acinetobacter baumannii outer membrane protein A. FEMS Immunology and Medical Microbiology, 54(1), 45–52. doi: 10.1111/j.1574-695X.2008.00446.x
Type
Article
ISSN
0928-8244
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1111/j.1574-695X.2008.00446.x
DOI
10.1111/j.1574-695X.2008.00446.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35741
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.