계명대학교 의학도서관 Repository

Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model

Metadata Downloads
Author(s)
Sang-Hyun KimSeung-Bin ParkSin-Myoung KangHoon JeonJong-Pil LimTaeg Kyu KwonWon-Hwan ParkHyung-Min KimTae-Yong Shin
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Food and Chemical Toxicology
Issued Date
2009
Volume
47
Issue
2
Abstract
The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as
asthma, allergic rhinitis, and sinusitis. Stimulation of mast cells starts the process of degranulation resulting
in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we
investigated the effect of aqueous extract of Teucrium japonicum Houttuyn (Labiatae) (AXTJ) on the mast
cell-mediated allergy model and studied its possible mechanisms of action. AXTJ inhibited compound
48/80-induced systemic reactions and serum histamine release in mice. AXTJ decreased immunoglobulin
E-mediated passive cutaneous anaphylaxis reaction. AXTJ reduced histamine release and intracellular
calcium from rat peritoneal mast cells activated by compound 48/80. In addition, AXTJ attenuated activation
of nuclear factor (NF)-jB, and downstream tumor necrosis factor (TNF)-a expression in phorbol
12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide
evidence that AXTJ inhibits mast cell-derived allergic reactions and involvement of intracellular calcium,
TNF-a, and NF-jB in these effects.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Sang-Hyun Kim et al. (2009). Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model. Food and Chemical Toxicology, 47(2), 398–403. doi: 10.1016/j.fct.2008.11.030
Type
Article
ISSN
0278-6915
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0278691508006637?via%3Dihub
DOI
10.1016/j.fct.2008.11.030
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35744
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.