계명대학교 의학도서관 Repository

Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38 MAPK phosphorylation

Metadata Downloads
Author(s)
Kyoung-jin MinHee Jung UmKyung-Hyun ChoTaeg Kyu Kwon
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Food and Chemical Toxicology
Issued Date
2013
Volume
58
Abstract
The uptake of oxidized low density lipoprotein (oxLDL) via scavenger receptors transforms macrophages
into foam cells, which are a hallmark of atherosclerosis. OxLDL markedly increases the expression of the
CD36 scavenger receptor. Here, we investigated whether curcumin modulate CD36 expression in oxLDLtreated
RAW 264.7 murine macrophages. Our results showed that curcumin dramatically inhibits CD36
expression and foam cell formation. Furthermore, oxLDL-induced expression and activity of peroxisome
proliferator-activated receptor-gamma (PPAR-c), which is involved in CD36 expression, is also blocked in
curcumin-treated cells. OxLDL activates the mitogen-activated protein kinase (MAPK) signaling transduction
pathway, and p38 MAPK is associated with oxLDL-induced CD36 and PPAR-c expression. Overexpression
of dominant negative p38 MAPK blocks oxLDL-induced CD36 and PPAR-c expression.
Furthermore, curcumin markedly inhibits p38 MAPK phosphorylation. Taken together, our results suggest
that curcumin modulates oxLDL-induced CD36 expression and foam cell formation via the inhibition
of p38 MAPK phosphorylation in RAW 264.7 murine macrophages.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Kyoung-jin Min et al. (2013). Curcumin inhibits oxLDL-induced CD36 expression and foam cell
formation through the inhibition of p38 MAPK phosphorylation. Food and Chemical Toxicology, 58, 77–85. doi: 10.1016/j.fct.2013.04.008
Type
Article
ISSN
0278-6915
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0278691513002354?via%3Dihub
DOI
10.1016/j.fct.2013.04.008
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35748
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.