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Low molecular weight fucoidan ameliorating the chronic cisplatin-induced delayed gastrointestinal motility in rats

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Author(s)
Moon Yong SongSae Kwang KuHyun Jee KimJin Soo Han
Keimyung Author(s)
Kim, Hyun Jee
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Food and Chemical Toxicology
Issued Date
2012
Volume
50
Issue
12
Abstract
Delayed gastrointestinal (GI) motility is frequent adverse effect associated with chemotherapy due to oxidative
stress, activation of 5-HT3 receptors or serotonin releases from enterochromaffin cells. Fucoidan,
extracts from brown seaweeds, has been showed antioxidant related favorable pharmacological activities
including digestive tract protective effects. Low molecular weight fucoidan (LMF) obtained by acid hydrolysis
of high molecular weight fucoidan has been showed more favorable bioactivities. This study was
conducted to determine whether or not LMF can prevent delayed GI motility induced by the antineoplastic
drug cisplatin chronically administered, once per week for five consecutive weeks. LMF ameliorating
the chronic cisplatin treatment related body weight decreases, delayed GI motility, and enhanced the
antioxidant defense systems. In addition, LMF also inhibited the cisplatin treatment related GI gastrin
and serotonin changes, including enzyme activities involved in serotonin metabolism and enterochromaffin
cells. The overall effects of LMF 10 mg/kg were similar to that of ondansetron 1 mg/kg, a serotonin
5-HT3 receptor antagonist. The present results supported that LMF have favorable ameliorating effect on
the delayed GI motility induced by chemotherapy, modulated the GI enterochromaffin cells, serotonin
and gastrin-producing cells with antioxidant effects. This effect of LMF may help improve accompanying
digestive disorders by chemotherapy.
Keimyung Author(s)(Kor)
김현지
Publisher
School of Medicine
Citation
Moon Yong Song et al. (2012). Low molecular weight fucoidan ameliorating the chronic cisplatin-induced
delayed gastrointestinal motility in rats. Food and Chemical Toxicology, 50(12), 4468–4478. doi: 10.1016/j.fct.2012.09.020
Type
Article
ISSN
0278-6915
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S027869151200693X?via%3Dihub
DOI
10.1016/j.fct.2012.09.020
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35750
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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