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Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells

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Author(s)
Min Ho HanWon Sup LeeJi Hyun JungJae-Hun JeongCheol ParkHye Jung KimGonSup KimJin-Myung JungTaeg Kyu KwonGi-Young KimChung Ho RyuSung Chul ShinSoon Chan HongYung Hyun Choi
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Food and Chemical Toxicology
Issued Date
2013
Volume
62
Abstract
Allium cepa Linn is commonly used as supplementary folk remedy for cancer therapy. Evidence suggests
that Allium extracts have anti-cancer properties. However, the mechanisms of the anti-cancer activity of
A. cepa Linn are not fully elucidated in human cancer cells. In this study, we investigated anti-cancer
effects of polyphenols extracted from lyophilized A. cepa Linn (PEAL) in human leukemia cells and their
mechanisms. PEAL inhibited cancer cell growth by inducing caspase-dependent apoptosis. The apoptosis
was suppressed by caspase 8 and 9 inhibitors. PEAL also up-regulated TNF-related apoptosis-inducing
ligand (TRAIL) receptor DR5 and down-regulated survivin and cellular inhibitor of apoptosis 1 (cIAP-1).
We confirmed these findings in other leukemic cells (THP-1, K562 cells). In addition, PEAL suppressed
Akt activity and the PEAL-induced apoptosis was significantly attenuated in Akt-overexpressing U937
cells. In conclusion, our data suggested that PEAL induced caspase-dependent apoptosis in several human
leukemic cells including U937 cells. The apoptosis was triggered through extrinsic pathway by up-regulating
DR5 modulating as well as through intrinsic pathway by modulating IAP family members. In addition,
PEAL induces caspase-dependent apoptosis at least in part through the inhibition of
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. This study provides evidence that PEAL
might be useful for the treatment of leukemia.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Min Ho Han et al. (2013). Polyphenols isolated from Allium cepa L. induces apoptosis
by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways
in human leukemic cells. Food and Chemical Toxicology, 62, 382–389. doi: 10.1016/j.fct.2013.08.085
Type
Article
ISSN
0278-6915
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0278691513006315?via%3Dihub
DOI
10.1016/j.fct.2013.08.085
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35751
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1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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