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Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes

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Author(s)
Sang-Hyun KimSoyoung LeeIn Kyeom KimTaeg Kyu KwonJin-Young MoonWon-Hwan ParkTae-Yong Shin
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Food and Chemical Toxicology
Issued Date
2007
Volume
45
Issue
11
Abstract
The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis and
sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array
of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of Amomum xanthiodes (Zingiberaceae) (AXE) on
the mast cell-mediated allergy model and studied its possible mechanisms of action. AXE inhibited compound 48/80-induced systemic
reactions and serum histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction.
AXE reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore,
AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase and c-jun
N-terminal kinase, and downstream tumor necrosis factor (TNF)-a production in phorbol 12-myristate 13-acetate and calcium ionophore
A23187-stimulated human mast cells. Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and
that intracellular calcium, TNF-a, and p38 MAPK are involved in these effects.
2007 Elsevier Ltd. All rights reserved.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Sang-Hyun Kim et al. (2007). Suppression of mast cell-mediated allergic reaction by
Amomum xanthiodes. Food and Chemical Toxicology, 45(11), 2138–2144. doi: 10.1016/j.fct.2007.05.011
Type
Article
ISSN
0278-6915
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0278691507001731?via%3Dihub
DOI
10.1016/j.fct.2007.05.011
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35753
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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