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Association between Interferon-Inducible Protein 6 (IFI6) Polymorphisms and Hepatitis B Virus Clearance

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Author(s)
Geun-Hee ParkKyoung-Yeon KimSung Won ChoJae Youn CheongGyeong Im YuDong Hoon ShinKyu Bum Kwack
Keimyung Author(s)
Shin, Dong Hoon
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
Genomics & Informatics
Issued Date
2013
Volume
11
Issue
1
Abstract
CD8+ T cells are key factors mediating hepatitis B virus (HBV) clearance. However, these cells are killed through HBV-induced
apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. Interferon-inducible
protein 6 (IFI6) delays type I interferon-induced apoptosis in cells. We hypothesized that single nucleotide polymorphisms
(SNPs) in the IFI6 could affect the chronicity of CLD. The present study included a discovery stage, in which 195 CLD patients,
including chronic hepatitis B (HEP) and cirrhosis patients and 107 spontaneous recovery (SR) controls, were analyzed. The
genotype distributions of rs2808426 (C > T) and rs10902662 (C > T) were significantly different between the SR and HEP
groups (odds ratio [OR], 6.60; 95% confidence interval [CI], 1.64 to 26.52, p = 0.008 for both SNPs) and between the SR and
CLD groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). The
distribution of diplotypes that contained these SNPs was significantly different between the SR and HEP groups (OR, 6.58;
95% CI, 1.63 to 25.59; p = 0.008 and OR, 0.15; 95% CI, 0.04 to 0.61; p = 0.008, respectively) and between the SR and CLD
groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). We were
unable to replicate the association shown by secondary enrolled samples. A large-scale validation study should be performed
to confirm the association between IFI6 and HBV clearance.
Keywords: hepatitis B virus, IFI6, single nucleotide polymorphism
Keimyung Author(s)(Kor)
신동훈
Publisher
School of Medicine
Citation
Geun-Hee Park et al. (2013). Association between Interferon-Inducible Protein 6
(IFI6) Polymorphisms and Hepatitis B Virus Clearance. Genomics & Informatics, 11(1), 15–23. doi: 10.5808/GI.2013.11.1.15
Type
Article
ISSN
1598-866X
DOI
10.5808/GI.2013.11.1.15
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35776
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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