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Comparison of clinical outcomes of adenocarcinoma and adenosquamous carcinoma in uterine cervical cancer patients receiving surgical resection followed by radiotherapy: A multicenter retrospective study (KROG 13-10)

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Author(s)
Jae Myoung NohWon ParkYoung Seok KimJoo-Young KimHak Jae KimJuree KimJin Hee KimMee Sun YoonJin Hwa ChoiWon Sup YoonJi-Yoon KimSeung Jae Huh
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Gynecologic Oncology
Issued Date
2014
Volume
132
Issue
3
Abstract
Objective. To evaluate the prognostic influence of adenocarcinoma (AC) and adenosquamous carcinoma
(ASC) in patients with FIGO stage IB–IIA cervical cancerwho received radical hysterectomy followed by adjuvant
radiotherapy (RT) or concurrent chemoradiotherapy (CCRT).
Methods. We analyzed 1323 patients who satisfied the following criteria: histologically proven squamous
cell carcinoma (SCC), AC, or ASC of the uterine cervix; FIGO stage IB–IIA disease; no history of neoadjuvant
chemotherapy; and a history of radical hysterectomy with pelvic lymph node (PLN) dissection, followed by
postoperative pelvic RT at a dose ≥45 Gy. The median age was 50 years. Median RT dose delivered to
the whole pelvis was 50.4 Gy, and 219 (16.6%) patients received brachytherapy at a median dose of 24 Gy.
Concurrent chemotherapy was delivered to 492 (37.2%) patients.
Results. Pathologic risk factors were not different according to pathologic subtype. The median follow-up
duration was 75.7 months. Locoregional recurrence-free survival, relapse-free survival (RFS), and overall
survival were significantly affected by histology, tumor size, PLN metastasis, parametrial invasion,
lymphovascular invasion, and deep stromal invasion. The 5-year RFS rates were 83.7%, 66.5%, and 79.6%
in patients with SCC, AC, and ASC histology, respectively (P b 0.0001). Bymultivariate analysis, AC histology
was the only significant prognostic factor affecting all survival outcomes.
Conclusions. AC histology was associated with poor survival outcomes in patients with FIGO stage IB–IIA
cervical cancer who received adjuvant RT or CCRT. Prognosis of ASC histology was closer to that of SCC
histology than that of AC histology.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine
Citation
Jae Myoung Noh et al. (2014). Comparison of clinical outcomes of adenocarcinoma and
adenosquamous carcinoma in uterine cervical cancer patients receiving
surgical resection followed by radiotherapy: A multicenter retrospective
study (KROG 13-10). Gynecologic Oncology, 132(3), 618–623. doi: 10.1016/j.ygyno.2014.01.043
Type
Article
ISSN
0090-8258
Source
https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(14)00103-6
DOI
10.1016/j.ygyno.2014.01.043
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35791
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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