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Outcomes of ovarian preservation in a cohort of premenopausal women with early-stage endometrial cancer: A Korean Gynecologic Oncology Group study

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Author(s)
Taek Sang LeeJung-Yun LeeJae-Weon KimSohee OhSeok Ju SeongJong Min LeeTae Jin KimChi Heum ChoSeok-Mo KimChan-Yong Park
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Gynecologic Oncology
Issued Date
2013
Volume
131
Issue
2
Abstract
Objective. The aimof this study was to evaluate the impact of ovarian preservation on the recurrence and survival
rates of premenopausal women with early-stage endometrial cancer.
Methods. Using medical records of premenopausalwomenwho received primary surgical treatment for stage
I–II endometrial cancer, the demographics and survival rates were compared retrospectively for patients who
had ovarian preservation and those who underwent bilateral salpingo-oophorectomy. Cox proportional hazards
models with inverse probability of treatment weighting (IPTW) based on propensity score were performed to
adjust for selection bias between the two groups.
Results. A total of 495 women were identified, including 176 patients who had ovarian preservation. The
ovarian preservation group was younger (P b 0.001) and had an earlier year of diagnosis (P = 0.014), a lower
prevalence of lymphadenectomy (P b 0.001), and a marginally significant association with lower tumor grade
(P = 0.052). The Kaplan–Meier curve and the log rank test showed no difference in either recurrence-free survival
(P = 0.742) or overall survival (P = 0.462) between the two groups. In a multivariate Cox model adjusted
by IPTWand covariates, ovarian preservation had no effect on either recurrence (hazard ratio [HR], 0.73; 95% CI,
0.29–1.81) or overall survival (HR, 1.33; 95% CI, 0.43–4.09).
Conclusions. Ovarian preservation does not appear to be associated with an adverse impact on the outcomes
of premenopausal women with early-stage endometrial cancer. The present study has useful implications for
physicians counseling young women who want to preserve their ovaries.
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
Taek Sang Lee et al. (2013). Outcomes of ovarian preservation in a cohort of premenopausal women
with early-stage endometrial cancer: A Korean Gynecologic Oncology
Group study. Gynecologic Oncology, 131(2), 289–293. doi: 10.1016/j.ygyno.2013.08.024
Type
Article
ISSN
0090-8258
Source
https://www.sciencedirect.com/science/article/pii/S0090825813011098?via%3Dihub
DOI
10.1016/j.ygyno.2013.08.024
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35793
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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