계명대학교 의학도서관 Repository

Can combination of osteopontin and peritumor-infiltrating macrophages be a prognostic marker of early-stage hepatocellular carcinoma?

Metadata Downloads
Affiliated Author(s)
이유진장병국
Alternative Author(s)
Lee, Yoo JinJang, Byoung Kuk
Journal Title
HepatoBiliary Surgery and Nutrition
ISSN
2304-3881
Issued Date
2014
Abstract
Hepatocellular carcinoma (HCC) is one of the most frequent malignancy worldwide. The
increasing incidence of HCC in the worldwide has sparked an emerging interest in prognostic markers of
HCC. Osteopontin (OPN) is a secreted phosphoprotein which has been associated with progression and
metastasis of HCC. Also, peritumoral macrophage (PTM) have been reported to facilitate tumor progression
and metastasis. Recently, one study reported that combination of OPN with PTM may predict the prognosis
of HCC after curative resection. The authors successfully identified that combination of these two markers
is an independent predictor of tumor recurrence and survival in patients with HCC, especially for those with
early-stage disease. These findings might support the possibility that combination of OPN and PTM levels
can be a prognostic tool. However, further investigations should be conducted before tumor OPN combined
with PTMs can be accepted as a valid prognostic marker in clinical practice.
Keywords: Osteopontin (OPN); peritumoral infiltrating macrophages; prognosis; marker; hepatocellular
carcinoma (HCC)
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Yoo Jin Lee and Byoung Kuk Jang. (2014). Can combination of osteopontin and peritumor-infiltrating
macrophages be a prognostic marker of early-stage
hepatocellular carcinoma? HepatoBiliary Surgery and Nutrition, 3(2), 57–59. doi: 10.3978/j.issn.2304-3881.2014.02.11
Type
Article
ISSN
2304-3881
DOI
10.3978/j.issn.2304-3881.2014.02.11
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35816
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.