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Autologous stem cell transplantation for expansion of remnant liver volume with extensive hepatectomy

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Author(s)
Han HSAhn KSCho JYYoon YSYoon CJPark KUMin SKLee HKRyu KH
Keimyung Author(s)
Ahn, Keun Soo
Department
Dept. of Surgery (외과학)
Journal Title
Hepato-gastroenterology
Issued Date
2014
Volume
61
Issue
61
Abstract
Abstract

BACKGROUND/AIMS:

The plasticity of bone marrow stem cells has been confirmed to self-renew and transdifferentiate into hepatocytes. Thus, we performed autologous stem cell transplantation for rapid liver regeneration with extensive hepatectomy in hepatocellular cancer patients.

METHODOLOGY:

With informed consent, patients aged 20 to 75 who needed large extensive hepatectomy due to hepatocellular carcinoma were randomly divided into three groups: control, mononuclear cells (MNCs), and CD34+ cells, based on infused cell type. After portal vein embolization (PVE), mobilized MNCs or CD34+ cells were returned to the patient via the portal vein on mobilization day without manipulation. Liver volume, liver function, clinical score and Indocyanine green R15 (ICG-R15) were compared before and after PVE.

RESULTS:

Total bilirubin, albumin, and clinical score showed significant improvement (p < 0.05) 1 week post-infusion, with no significant difference between MNC and CD34+ cell groups. Four patients (control, 1; MNC, 1; CD34+, 2) started at over 18% ICG-R15 but can be overturned after PVE. Daily hepatic volume growth (mL/day) was 2.5 for MNC and 4.9 for CD34+ groups, resulting in significant increase over controls (1.1; p < 0.05). We found no correlation between the number of applied CD34+ cells and daily gains in left lateral lobe volume.

CONCLUSIONS:

Improvements in liver volume, liver function, clinical score and ICG-R15 suggest that autologous stem cell transplantation is a promising method for liver regeneration.
Keimyung Author(s)(Kor)
안근수
Publisher
School of Medicine
Citation
Han HS et al. (2014). Autologous stem cell transplantation for expansion of remnant liver volume with extensive hepatectomy. Hepato-gastroenterology, 61(61), 129–129. doi: 10.5754/hge13178
Type
Article
ISSN
0172-6390
Source
http://europepmc.org/abstract/MED/24895813
DOI
10.5754/hge13178
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35818
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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