계명대학교 의학도서관 Repository

Response failure to the treatment of Clostridium difficile infection and its impact on 30-day mortality

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Author(s)
Kim ESKim YJPark CWCho KBJang BKChung WJHwang JSPark KS
Keimyung Author(s)
Kim, Eun SooCho, Kwang BumJang, Byoung KukChung, Woo JinHwang, Jae SeokPark, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Hepato-gastroenterology
Issued Date
2013
Volume
60
Issue
123
Abstract
Abstract

BACKGROUND/AIMS:

Few data are available on response failure and hospital mortality. This study aimed to evaluate the association between response failure to the treatment of CDI and 30-day mortality.

METHODS:

Medical records of patients diagnosed with CDI between March 2005 and March 2010 were reviewed. CDI diagnosis was considered in patients with diarrhea when the stool toxins assay was positive or pseudomembranous colitis (PMC) was confirmed by endoscopy. If there were no symptomatic improvements during 10 days of treatment, the case was regarded as response failure. Patients were stratified into a mild or severe disease group based on clinical criteria.

RESULTS:

Among 536 subjects (age 64±14.12, mild 266, severe 270), 26 (4.9%) showed response failure, which occurred more frequently in the severe disease than mild disease group. Forty-eight (9%) patients died within 1 month and mortality rate in the failure group was higher than in the response group (42.3% vs. 7.3%, p<0.001). Malignancy, albumin <2.5 mg/dL, WBC >15,000 cells/mm3, ICU admission and response failure were independent risk factors associated with 30-day mortality after CDI.

CONCLUSIONS:

Response failure to the treatment negatively affects a patients’ survival within 30 days after CDI.
Keimyung Author(s)(Kor)
김은수
조광범
장병국
정우진
황재석
박경식
Publisher
School of Medicine
Citation
Kim ES et al. (2013). Response failure to the treatment of Clostridium difficile infection and its impact on 30-day mortality. Hepato-gastroenterology, 60(123), 543–548. doi: 10.5754/hge0851
Type
Article
ISSN
0172-6390
Source
http://europepmc.org/abstract/med/23108084
DOI
10.5754/hge0851
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35820
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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