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Alpha-Lipoic Acid Decreases Hepatic Lipogenesis Through Adenosine Monophosphate-Activated Protein Kinase (AMPK)-Dependent and AMPK-Independent Pathways

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Author(s)
Keun-Gyu ParkAe-Kyung MinEun Hee KohHyoun Sik KimMi-Ok KimHye-Sun ParkYong-Deuk KimTae-Seung YoonByoung Kuk JangJae Seok HwangJae Bum KimHueng-Sik ChoiJoong-Yeol ParkIn-Kyu LeeKi-Up Lee
Keimyung Author(s)
Park, Keun GyuJang, Byoung KukHwang, Jae Seok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Hepatology
Issued Date
2008
Volume
48
Issue
5
Abstract
Fatty liver is common in obese subjects with insulin resistance. Hepatic expression of sterol regulatory element binding protein-1c (SREBP-1c), which plays a major role in hepatic steatosis, is regulated by multiple factors, including insulin, adenosine monophosphate–activated protein kinase (AMPK), liver X receptors (LXRs), and specificity protein 1. Alpha-lipoic acid (ALA), a naturally occurring antioxidant, has been shown to decrease lipid accumulation in skeletal muscle by activating AMPK. Here we show that ALA decreases hepatic steatosis and SREBP-1c expression in rats on a high fat diet or given an LXR agonist. ALA increased AMPK phosphorylation in the liver and in cultured liver cells, and dominant-negative AMPK partially prevented ALA-induced suppression of insulin-stimulated SREBP-1c expression. ALA also inhibited DNA-binding activity and transcriptional activity of both specificity protein 1 and LXR. Conclusion: These results show that ALA prevents fatty liver disease through multiple mechanisms, and suggest that ALA can be used to prevent the development and progression of nonalcoholic fatty liver disease in patients with insulin resistance. (HEPATOLOGY 2008.)
Keimyung Author(s)(Kor)
박근규
장병국
황재석
Publisher
School of Medicine
Citation
Keun-Gyu Park et al. (2008). Alpha-Lipoic Acid Decreases Hepatic Lipogenesis
Through Adenosine Monophosphate-Activated Protein
Kinase (AMPK)-Dependent and AMPK-Independent
Pathways. Hepatology, 48(5), 1477–1486. doi: 10.1002/hep.22496
Type
Article
ISSN
0270-9139
DOI
10.1002/hep.22496
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35824
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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