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Differential expression of forkhead box M1 and its downstream cyclin-dependent kinase inhibitors p27kip1 and p21waf1/cip1 in the diagnosis of pulmonary neuroendocrine tumours

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Author(s)
Seung Yeon HaChang Hun LeeHee Kyung ChangSunhee ChangKun Young KwonEun Hee LeeMee Sook RohBoram Seo
Keimyung Author(s)
Kwon, Kun Young
Department
Dept. of Pathology (병리학)
Journal Title
Histopathology
Issued Date
2012
Volume
60
Issue
5
Abstract
Keywords:

Forkhead box M1;
lung;
neuroendocrine tumour;
p21waf1/cip1;
p27kip1



Ha S Y, Lee C H, Chang H K, Chang S, Kwon K Y, Lee E H, Roh M S & Seo B (2012) Histopathology 60, 731–739 Differential expression of forkhead box M1 and its downstream cyclin-dependent kinase inhibitors p27kip1 and p21waf1/cip1 in the diagnosis of pulmonary neuroendocrine tumours


Aims:  Pulmonary neuroendocrine (NE) tumours represent a spectrum of phenotypically distinct entities with different biological behaviours. Difficulties in classifying these tumours are frequently encountered in clinical practice. Forkhead box M1 (FoxM1) is essential for the development of various cancers and is a proliferation-specific transcription factor that regulates transcription of cell cycle genes, including cyclin-dependent kinase inhibitors p27kip1 and p21waf1/cip1. This study was performed to determine the utility of FoxM1, p27kip1 and p21waf1/cip1 as immunomarkers for subtyping pulmonary NE tumours.


Methods and results:  FoxM1, p27kip1 and p21waf1/cip1 expression was evaluated by immunohistochemistry in 60 pulmonary NE tumours [19 typical carcinoids (TCs), six atypical carcinoids (ACs), 17 large cell neuroendocrine carcinomas (LCNECs) and 18 small cell lung cancers (SCLCs)]. The frequencies of FoxM1 and p21waf1/cip1 expression were significantly different between TCs and ACs (each P = 0.009), and those of FoxM1 and p27kip1 expression were significantly different between LCNECs and SCLCs (P = 0.012 and P = 0.002, respectively). The combined FoxM1(−)/p21waf1/cip1(−) and FoxM1(+)/p27kip1(high) phenotypes had the best diagnostic accuracy for distinguishing TCs from ACs, and SCLCs from LCNECs, respectively.


Conclusions:  FoxM1, p27kip1 and p21waf1/cip1 showed distinct immunoreactivity according to histological subtype, which may be of value as an ancillary test in the differential diagnosis of pulmonary NE tumours.
Keimyung Author(s)(Kor)
권건영
Publisher
School of Medicine
Citation
Seung Yeon Ha et al. (2012). Differential expression of forkhead box M1 and its
downstream cyclin-dependent kinase inhibitors p27kip1 and
p21waf1/cip1 in the diagnosis of pulmonary neuroendocrine tumours. Histopathology, 60(5), 731–739. doi: 10.1111/j.1365-2559.2011.04137.x
Type
Article
ISSN
0309-0167
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1111/j.1365-2559.2011.04137.x
DOI
10.1111/j.1365-2559.2011.04137.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35833
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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