Neuroendocrine differentiation correlates with hormone
receptor expression and decreased survival in patients with
invasive breast carcinoma
- Author(s)
- Sun Young Kwon; Young Kyung Bae; Mi Jin Gu; Jung Eun Choi; Su Hwan Kang; Soo Jung Lee; Aeri Kim; Hye Ra Jung; Sun Hee Kang; Hoon Kyu Oh; Ji Young Park
- Keimyung Author(s)
- Kwon, Sun Young; Jung, Hye Ra; Oh, Hoon Kyu; Kang, Sun Hee
- Department
- Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
- Journal Title
- Histopathology
- Issued Date
- 2014
- Volume
- 64
- Issue
- 5
- Abstract
- Keywords:
breast neoplasms;
neuroendocrine differentiation;
prognosis
Aims
Invasive breast carcinoma (IBC) with neuroendocrine (NE) differentiation has been controversial in terms of its definition and clinical outcome. We investigated the incidence and clinical significance of NE differentiation in patients with IBC.
Methods and results
We performed immunohistochemistry for NE markers, chromogranin-A and synaptophysin on 1428 IBC samples using tissue microarrays and classified cases with NE differentiation into two groups, focal (1–49% tumour cells positive for any NE marker) and diffuse (≥50% tumour cells positive) groups. Fifty-nine cases (4.1%) showed NE differentiation immunohistochemically, and the majority did not show typical NE morphology. The presence of NE differentiation showed a significant association with positive oestrogen receptor (P = 0.001) and progesterone receptor (P = 0.008) status. Patients with NE differentiation showed worse overall survival (OS) and disease-free survival (DFS) than those without NE differentiation in both univariate (P < 0.001 for both) and multivariate (OS, P = 0.004; DFS, P < 0.001) analyses.
Conclusions
IBC with NE differentiation is a distinct subtype of mammary carcinoma with an aggressive clinical outcome.
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