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Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma

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Author(s)
Sun Young KwonYoung Kyung BaeMi Jin GuJung Eun ChoiSu Hwan KangSoo Jung LeeAeri KimHye Ra JungSun Hee KangHoon Kyu OhJi Young Park
Keimyung Author(s)
Kwon, Sun YoungJung, Hye RaOh, Hoon KyuKang, Sun Hee
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Journal Title
Histopathology
Issued Date
2014
Volume
64
Issue
5
Abstract
Keywords:

breast neoplasms;
neuroendocrine differentiation;
prognosis



Aims


Invasive breast carcinoma (IBC) with neuroendocrine (NE) differentiation has been controversial in terms of its definition and clinical outcome. We investigated the incidence and clinical significance of NE differentiation in patients with IBC.


Methods and results


We performed immunohistochemistry for NE markers, chromogranin-A and synaptophysin on 1428 IBC samples using tissue microarrays and classified cases with NE differentiation into two groups, focal (1–49% tumour cells positive for any NE marker) and diffuse (≥50% tumour cells positive) groups. Fifty-nine cases (4.1%) showed NE differentiation immunohistochemically, and the majority did not show typical NE morphology. The presence of NE differentiation showed a significant association with positive oestrogen receptor (P = 0.001) and progesterone receptor (P = 0.008) status. Patients with NE differentiation showed worse overall survival (OS) and disease-free survival (DFS) than those without NE differentiation in both univariate (P < 0.001 for both) and multivariate (OS, P = 0.004; DFS, P < 0.001) analyses.


Conclusions


IBC with NE differentiation is a distinct subtype of mammary carcinoma with an aggressive clinical outcome.
Keimyung Author(s)(Kor)
권선영
정혜라
오훈규
강선희
Publisher
School of Medicine
Citation
Sun Young Kwon et al. (2014). Neuroendocrine differentiation correlates with hormone
receptor expression and decreased survival in patients with
invasive breast carcinoma. Histopathology, 64(5), 647–59. doi: 10.1111/his.12306
Type
Article
ISSN
0309-0167
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1111/his.12306
DOI
10.1111/his.12306
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35834
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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