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Inhibitory Effect of Nuclear Factor-кB Decoy Oligodeoxynucleotide on Liver Fibrosis Through Regulation of the Epithelial–Mesenchymal Transition

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Author(s)
Kyung-Hyun KimWoo-Ram LeeYu-Na KangYoung-Chae ChangKwan-Kyu Park
Keimyung Author(s)
Kang, Yu Na
Department
Dept. of Pathology (병리학)
Journal Title
Human Gene Therapy
Issued Date
2014
Volume
25
Issue
8
Abstract
The epithelial–mesenchymal transition (EMT) has been recognized to occur during embryonic development,
fibrosis, and tumor metastasis. Nuclear factor (NF)-jB plays a central role in mediating the inflammation and
wound-healing responses during liver fibrogenesis. However, the involvement of NF-jB during EMT in liver
cells remains unidentified. To develop a therapeutic approach to EMT during liver fibrosis, we examined the
inhibition of transcription factor NF-jB, using a decoy oligodeoxynucleotide (ODN) strategy in liver fibrosis
in vitro and in vivo. NF-jB decoy ODN contains consensus binding sequences of the NF-jB-binding site.
NF-jB decoy ODN effectively suppresses transforming growth factor-b1-induced EMT in AML12 murine
hepatocytes. Liver fibrosis induced by CCl4 administration was suppressed by NF-jB decoy ODN. Furthermore,
NF-jB decoy ODN was shown to inhibit the EMT process in fibrotic liver in vivo. This study demonstrates
the feasibility of NF-jB decoy ODN treatment for preventing liver fibrosis via EMT processes
Keimyung Author(s)(Kor)
강유나
Publisher
School of Medicine
Citation
Kyung-Hyun Kim et al. (2014). Inhibitory Effect of Nuclear Factor-кB Decoy
Oligodeoxynucleotide on Liver Fibrosis Through
Regulation of the Epithelial–Mesenchymal Transition. Human Gene Therapy, 25(8), 721–729. doi: 10.1089/hum.2013.106
Type
Article
ISSN
1043-0342
Source
https://www.liebertpub.com/doi/abs/10.1089/hum.2013.106
DOI
10.1089/hum.2013.106
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35837
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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