Meta-analysis of genome-wide association studies
in East Asian-ancestry populations identifies four
new loci for body mass index
- Affiliated Author(s)
- 신동훈
- Alternative Author(s)
- Shin, Dong Hoon
- Journal Title
- Human Molecular Genetics
- ISSN
- 0964-6906
- Issued Date
- 2014
- Abstract
- Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index
(BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a
meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms
among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among
7488–47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the
KCNQ1 (rs2237892, P 5 9.29 3 10213), ALDH2/MYL2 (rs671, P 5 3.40 3 10211; rs12229654, P 5 4.56 3 1029),
ITIH4 (rs2535633, P 5 1.77 3 10210) and NT5C2 (rs11191580, P 5 3.83 3 1028) genes. The association of BMI
with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51
BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at
the genome-wide significance level (P < 5.0 3 1028) and an additional 14 at P < 1.0 3 1023 with the same direction
of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis
of obesity.
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