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Safety of quetiapine fumarate extended release in the treatment of Korean patients with acute schizophrenia

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Author(s)
Chang-Yoon KimJin-Sang YoonSo-Young YooYoung-Hoon KimJung-Goo LeeJong-Il LeeYang-Tae KimChul-Eung Kim
Keimyung Author(s)
Kim, Yang Tae
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Human Psychopharmacology
Issued Date
2012
Volume
27
Issue
4
Abstract
Introduction The aim of this study was to evaluate the effi cacy and safety of quetiapine fumarate extended release (XR) in the treatment of
Korean subjects with acute schizophrenia.
Methods This was an 8-week, multi-center, open-label, non-comparative study to evaluate the efficacy and safety of quetiapine fumarate
XR at a daily dose of 400–800 mg. Changes in total scores on the Positive and Negative Syndrome Scale (PANSS) from baseline to week 8
were analyzed to evaluate the efficacy of quetiapine XR. Additionally, the Clinical Global Impression scale and the Montgomery–Åsberg
Depression Rating Scale were administered.
Results The mean change in PANSS total scores was 26.8, and the mean PANSS total score at the endpoint was significantly lower than
that at baseline. The mean PANSS positive score, negative score, and general score showed statistically significant reductions at the end of the
study. Statistically significant changes were also observed in Clinical Global Impression-Severity and Montgomery–Åsberg Depression
Rating Scale scores. The most common treatment-related adverse events in the group receiving quetiapine XR were sedation (10.6%) and
constipation (9.6%).
Conclusions In this study of Korean patients with acute schizophrenia, quetiapine XR showed clinical efficacy and relatively good
tolerability. Copyright © 2012 John Wiley & Sons, Ltd.
key words—schizophrenia; quetiapine fumarate extended release; efficacy; tolerability; titration
Keimyung Author(s)(Kor)
김양태
Publisher
School of Medicine
Citation
Chang-Yoon Kim et al. (2012). Safety of quetiapine fumarate extended release in the treatment of
Korean patients with acute schizophrenia. Human Psychopharmacology, 27(4), 403–410. doi: 10.1002/hup.2241
Type
Article
ISSN
0885-6222
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2241
DOI
10.1002/hup.2241
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35840
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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