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Renal Cell Carcinoma in South Korea: A Multicenter Study

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Author(s)
HAERYOUNG KIMNAM HOON CHODONG-SUG KIMYOUNG-MI KWONEUN KYUNG KIMSEO HEE RHAYONG WOOK PARKJUNG WEON SHIMSANG SOOK LEESHI NAE LEEJUHIE LEEJIN SOOK LEETAE-JIN LEESOO JIN JUNGSOON-HEE JUNGJIN HAENG CHUNGHYUN YEE CHOHEE JAE JOOYEONG-JIN CHOICHAN CHOIWOON SUP HANBANG HURJAE Y. RO
Keimyung Author(s)
Lee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Human Pathology
Issued Date
2004
Volume
35
Issue
12
Abstract
The incidence of renal cell carcinoma (RCC) in South Korea is
steadily becoming similar to that in Western countries. This study
summarizes the results of a 3-year multicenter survey of RCC in
South Korea, conducted by the Korean Genitourinary Pathology
Study Group. A total of 795 cases of RCC were collected from 20
institutes between 1995 and 1997, including 686 clear cell RCCs
(86.3%), 58 papillary RCCS (7.30%), 49 chromphobe RCCs (6.16%),
and 2 collecting duct RCCs (0.25%). At least 5 years of follow-up was
available for 627 clear cell, 54 papillary, and 49 chromophobe RCCs.
All subtypes presented most frequently with stage T3aN0M0 at the
time of operation, and papillary RCCs demonstrated more frequent
lymph node metastasis. Overall survival was not significantly related
to the histological subtype (clear cell vs papillary, P 0.8651; clear
cell vs chromophobe, P 0.0584; papillary vs chromophobe, P
0.0743). For clear cell RCCs, statistically significant associations were
found between overall survival and sex (P 0.0153), multiplicity (P
0.0461), necrosis (P 0.0191), age, sarcomatoid change, TNM
stage, nuclear grade, and modality of treatment (all P <0.0001).
Overall survival was significantly associated with tumor size (P
0.0307), nuclear grade (P 0.0235), multiplicity, sarcomatoid
change, and TNM stage (all P <0.0001) for papillary RCCs and with
the presence of sarcomatoid change (P 0.0281), nuclear grade (P
0.0015), treatment modality (P 0.0328), and TNM stage (P <0.0001)
for chromophobe RCCs. Age (P 0.0125), nodal stage (P 0.0010),
and treatment modality (P 0.0001) were significant independent prognostic
indicators for clear cell RCC on multivariate analysis. This is the
first multicenter study of RCC in South Korea, demonstrating the general
patterns and prognostic factors of Korean RCCs. HUM PATHOL 35:
1556-1563. © 2004 Elsevier Inc. All rights reserved.
Key words: renal cell carcinoma, survival, prognostic factor,
Korea.
Abbreviations: AJCC, American Joint Committee on Cancer; CT,
computed tomography; MRI, magnetic resonance imaging; RCC,
renal cell carcinoma; UICC, Union Internationale Contre le Cancer
Keimyung Author(s)(Kor)
이상숙
Publisher
School of Medicine
Citation
HAERYOUNG KIM et al. (2004). Renal Cell Carcinoma in South Korea:
A Multicenter Study. Human Pathology, 35(12), 1556–1563. doi: 10.1016/j.humpath.2004.06.011
Type
Article
ISSN
0046-8177
Source
https://www.sciencedirect.com/science/article/pii/S0046817704003648?via%3Dihub
DOI
10.1016/j.humpath.2004.06.011
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35842
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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