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Cilostazol Inhibits Vascular Smooth Muscle Cell Growth by Downregulation of the Transcription Factor E2F

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Affiliated Author(s)
박근규김혜순이인규김천수이상락
Alternative Author(s)
Park, Keun GyuKim, Hye SoonLee, In KyuKim, Chun SooLee, Sang Lak
Journal Title
Hypertension
ISSN
0194-911X
Issued Date
2005
Abstract
—Neointimal formation, the leading cause of restenosis, is caused by proliferation of vascular smooth muscle cells
(VSMCs). Patients with diabetes mellitus have higher restenosis rates after coronary angioplasty than nondiabetic
patients. Cilostazol, a selective type 3 phosphodiesterase inhibitor, is currently used to treat patients with diabetic
vascular complications. Cilostazol is a potent antiplatelet agent that inhibits VSMC proliferation. In the present study,
we examine whether the antiproliferative effect of cilostazol on VSMCs is mediated by inhibition of an important cell
cycle transcription factor, E2F. Cilostazol inhibited the proliferation of human VSMCs in response to high glucose in
vitro and virtually abolished neointimal formation in rats subjected to carotid artery injury in vivo. Moreover, the
compound suppressed high-glucose–induced E2F–DNA binding activity, and the expression of E2F1, E2F2, cyclin A,
and PCNA proteins. These data suggest that the beneficial effects of cilostazol on high-glucose–stimulated proliferation
of VSMCs are mediated by the downregulation of E2F activity and expression of its downstream target genes, including
E2F1, E2F2, cyclin A, and PCNA. (Hypertension. 2005;45:552-556.)
Department
Dept. of Internal Medicine (내과학)
Dept. of Pediatrics (소아청소년학)
Institute for Medical Science (의과학연구소)
Publisher
School of Medicine
Citation
Mi-Jung Kim et al. (2005). Cilostazol Inhibits Vascular Smooth Muscle Cell Growth by
Downregulation of the Transcription Factor E2F. Hypertension, 45(4), 552–556. doi: 10.1161/01.HYP.0000158263.64320.eb
Type
Article
ISSN
0194-911X
DOI
10.1161/01.HYP.0000158263.64320.eb
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35847
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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