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Gastric Carcinoma With Lymphoid Stroma

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Author(s)
Hye Jae ChoJung Yeon KimJinye YooSang Sook Lee
Keimyung Author(s)
Lee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Applied Immunohistochemistry & Molecular Morphology
Issued Date
2003
Volume
11
Issue
2
Abstract
Lymphoepithelioma-like carcinoma (LELC) of the stomach is
reported to be associated with Epstein-Barr virus (EBV) and to
have a better prognosis than typical adenocarcinoma. However,
the incidence of EBV and its association with Helicobacter
pylori is controversial. In our series, 9 of 370 (2.4%) cases of
gastric adenocarcinoma were LELC. Formalin-fixed, paraffinembedded
LELC tissue was immunostained with monoclonal
antibodies against CD3, CD20, and Ki-67. Warthin–Starry
stain for H. pylori and in situ hybridization for EBV were
performed. As a control, 21 cases of adenocarcinoma with
prominent lymphoid stroma were compared with LELC. The
most common location of LELC was the body of the stomach
(five cases), followed by the cardia (two cases), whereas the
antrum was the most common site for the control group. There
were no significant differences in age, sex, or lymph node
metastasis between the LELC and control groups. The mean
Ki-67 index was similar (38.2% in LELC versus 35.3% in
control). H. pylori was found in 2 LELC cases (22%) and 6
controls (28.5%). EBV was positive in 7 LELC cases (77.8%)
and 4 controls (19.0%). All patients with LELC are alive and
well, whereas three patients have died of their disease in the
control group. Although EBV appeared to be a contributing
factor, H. pylori had a minor role in LELC. There were no
clinicopathologic differences between LELC and the control
group, except for the location of the tumor in the body of the
stomach and the tendency toward a better prognosis in LELC.
Key Words: carcinoma, Epstein-Barr virus, Helicobacter pylori,
lymphoepithelioma, stomach
Keimyung Author(s)(Kor)
이상숙
Publisher
School of Medicine
Citation
Hye Jae Cho et al. (2003). Gastric Carcinoma With Lymphoid Stroma. Applied Immunohistochemistry & Molecular Morphology, 11(2), 149–152.
Type
Article
ISSN
1541-2016
Source
https://insights.ovid.com/pubmed?pmid=12777999
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35853
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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