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Intramuscular co-injection of naked DNA encoding HBV core antigen and Flt3 ligand suppresses anti-HBc antibody response

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Author(s)
Taeg Kyu KwonJong-Wook Park
Keimyung Author(s)
Kwon, Taeg KyuPark, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
Immunology letters
Issued Date
2002
Volume
81
Issue
3
Abstract
Flt3 ligand, a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of
dendritic cells secreting IL-12. Its potential use in a clinical setting has been suggested. Here, we studied the effect of in situ delivery
of Flt3 ligand plasmid (FL) on the antibody response induced by DNA vaccine encoding wild-type hepatitis B virus core antigen
(HBc/w). Intramuscular injection of FL increased the expression of DEC205 and the size of splenocytes, and immunization with
HBc/w or HBc/w-transfected EL-4 cells induced strong anti-HBc antibody responses in mice. However, intramuscular injection of
FL with HBc/w significantly suppressed HBc/w-induced antibody response in a dose-dependent manner. Suppression of immune
response by FL injection was the most prominent when FL and HBc/w were co-injected at the same time and the same site. These
results suggest that FL may inhibit humoral response induced by DNA-type vaccination, and DC locally expanded by FL may not
have proper functions for induction of humoral response. # 2002 Elsevier Science B.V. All rights reserved.
Keywords: Flt3 ligand; HBV core DNA vaccine; Antibody response
Keimyung Author(s)(Kor)
권택규
박종욱
Publisher
School of Medicine
Citation
Taeg Kyu Kwon and Jong-Wook Park. (2002). Intramuscular co-injection of naked DNA encoding HBV core
antigen and Flt3 ligand suppresses anti-HBc antibody response. Immunology letters, 81(3), 229–234. doi: 10.1016/S0165-2478(02)00039-1
Type
Article
ISSN
0165-2478
Source
https://www.sciencedirect.com/science/article/pii/S0165247802000391?via%3Dihub
DOI
10.1016/S0165-2478(02)00039-1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35855
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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