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A Novel der(16)t(3;16)(p25;q24) in a Patient with Ovarian Cancer

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Author(s)
KANG-WOO MINYONG-SUK MOONCHI-HUM CHOHONG-TAE KIM
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
In Vivo
Issued Date
2012
Volume
26
Issue
1
Abstract
. Background: Non-random simple chromosomal
aberrations in various malignancies provide important
insights into the molecular pathogenesis of human cancer.
Although extensive data exist on recurring chromosomal
abnormalities in hematological cancer, data on individual
solid tumor types remain limited. Here we present the case of
a patient with ovarian cancer with a specific chromosomal
abnormality. Case Report: Cytogenetic analysis utilized a Gbanding
technique, which was performed with direct culture
of the surgically removed cancer cells from a 23-year-old
woman with grade II ovarian serous cystadenocarcinoma.
The patient had no family history of ovarian cancer. Results:
We report a novel der(16)t(3;16)(p25;q24) accompanied by
terminal deletion of 3p25 as the simple chromosomal
aberration in this case. Conclusion: To the best of our
knowledge, no such translocation has been previously
reported. The present study supports the possible role of both
del(3)(p25) and the translocation t(3;16)(p25;q24) in
ovarian cancer; nevertheless, the significance of these
chromosomal changes in the development of ovarian cancer
remains unknown. The significance of this finding and its
role in the pathogenesis of ovarian cancer requires further
clarification.
Cytogenetic work-up has the potential of providing improved
diagnostic and prognostic tools. Cytogenetic data also provide
key background information for the recognition and
identification of genes involved in cancer and their
subsequent application in therapeutic development (1). The
mechanisms underlying chromosomal aberrations in tumor
cells are still obscure. Variable recurrent simple chromosomal
aberrations have been reported for different types of cancer,
including leukemia, lymphoma, and solid tumor. These single
chromosomal changes might be primary events implicated in
the initiation of the neoplastic process (2).
Ovarian cancer is the leading cause of death in women
with gynecological malignancies. The genetic mechanisms
underlying the initiation and progression of ovarian cancer
have not been well defined. More than 400 ovarian
carcinomas with karyotypically characterized chromosomal
abnormalities have been reported. Most of these are
characterized by highly complex karyotypes with polyploidy
and variable structural chromosomal changes (3). However,
some non-random structural chromosomal aberrations have
been found in ovarian cancer with common chromosomal
breakpoints. The most prevalent structural rearrangements
are deletions and unbalanced translocations primarily
involving 1p, 1q, 3p, 3q, 6q, 7p, 10q, 11p, and 19q (2, 4-9).
Here, we report an unbalanced der(16)t(3;16)(p25;q24) as
the simple chromosomal aberration in a patient with ovarian
serous cystadenocarcinoma. To the best of our knowledge,
no such translocation has been previously reported.
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
KANG-WOO MIN et al. (2012). A Novel der(16)t(3;16)(p25;q24)
in a Patient with Ovarian Cancer. In Vivo, 26(1), 71–74.
Type
Article
ISSN
0258-851X
Source
http://iv.iiarjournals.org/content/26/1/71.long
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35857
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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