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16S rRNA 유전자 염기서열 분석법으로 확진한 Staphylococcus lugdunensis에 의한 감염성 심내막염 1예

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Affiliated Author(s)
류성열김현아
Alternative Author(s)
Ryu, Seong YeolKim, Hyun Ah
Journal Title
Infection and Chemotherapy
ISSN
2093-2340
Issued Date
2011
Abstract
Staphylococcus lugdunensis is a Gram-positive, coagulase-negative Staphylococcus
(CNS) species that is found as a skin commensal and has been
implicated
in fulminant invasive diseases such as infective endocarditis. S. lugudunensis
infections resemble Staphylococcus aureus infections in terms of
virulence, tissue destruction and clinical course. Although correct identification
and determination of the susceptibility profile are important, some commercial
systems may misidentify S. lugdunensis . We report a case of native valve infective
endocarditis caused by S. lugdunensis , which was misidentified by the Vitek 2
system but identified correctly by 16S ribosomal RNA (rRNA) gene sequencing
in a 72-year-old male patient. The patient had multiple vegetations on his mitral
valve, and the largest one was found on the posterior mitral valve leaflet. It was 2.5
cm in size and hypermobile. Diffuse valvular abscess was also observed. He had
persistent bacteremia for appoximately 8 days, which was resolved after immediate
surgery and antibiotic therapy. When a patient with severe sepsis syndrome
grows S. aureus or CNS other than S. lugdunensis on a commercial automatic
culture system, the possibility of S. lugdunensis should be considered and further
confirmatory testing such as 16S rRNA sequencing may be very useful.
Alternative Title
Native Valve Infective Endocarditis due to Staphylococcus
lugdunensis Confirmed by 16S Ribosomal
RNA Sequencing
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
하영은 et al. (2011). 16S rRNA 유전자 염기서열 분석법으로 확진한 Staphylococcus
lugdunensis에 의한 감염성 심내막염 1예. Infection and Chemotherapy, 43(4), 372–376. doi: 10.3947/ic.2011.43.4.372
Type
Article
ISSN
2093-2340
DOI
10.3947/ic.2011.43.4.372
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35865
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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