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Serratia Bacteremia in a Large University Hospital: Trends in Antibiotic Resistance During 10 Years and Implications for Antibiotic Use

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Author(s)
Sang‐Ho ChoiYang Soo KimJin‐Won ChungTae Hyong KimEun Ju ChooMi‐Na KimBaek‐Nam KimNam Joong KimJun Hee WooJiso Ryu
Keimyung Author(s)
Kim, Baek Nam
Department
Dept. of Internal Medicine (내과학)
Journal Title
Infection Control and Hospital Epidemiology
Issued Date
2002
Volume
23
Issue
12
Abstract
Objective: To identify antibiotic resistance trends and risk factors for resistance of Serratia species to third-generation cephalosporins. Design: Retrospective survey of medical records. Setting: A 2,200-bed, tertiary-care hospital. Patients: One hundred twenty-two patients with Serratia bacteremia between January 1991 and June 2001. Methods: Infectious disease physicians collected data from medical records regarding patient demographics, underlying disease or condition, portal of entry, microorganism, antibiogram, complications, antibiotics received, and outcome. Results: Among 122 Serratia isolates, 117 (95.9%) were Serratia marcescens and 110 (90.2%) were of nosocomial origin. During the study period, the 122 isolates showed a high rate of resistance to third-generation cephalosporins (45.9%) and extended-spectrum penicillins (56.6%). The resistance rate to ciprofloxacin was 32.0%. The resistance rate to third-generation cephalosporins increased from 31.7% for 1991 to 1995 to 54.9% for 1996 to 1998 and 50.0% for 1999 to 2001. In the multivariate analysis, prior use of a second-generation cephalosporin (adjusted odds ratio [OR], 5.90; 95% confidence interval [$CI{95}$], 1.41 to 24.6; P = .015) or a third-generation cephalosporin (OR, 3.26;$CI{95}$, 1.20 to 8.87; P = .020) was a strong independent risk factor for resistance to third-generation cephalosporins. The overall case-fatality rate was 25.4% (Serratia bacteremia-related case-fatality rate, 13.1%). Conclusion: Prior use of a second- or third-generation cephalosporin was the most important risk factor for bacteremia with Serratia resistant to third-generation cephalosporins, suggesting the need for antibiotic control. The potential role of patientto-patient spread could not be fully evaluated in this retrospective study.
Keimyung Author(s)(Kor)
김백남
Publisher
School of Medicine
Citation
Sang‐Ho Choi et al. (2002). Serratia Bacteremia in a Large University Hospital: Trends in Antibiotic Resistance During 10 Years and Implications for Antibiotic Use. Infection Control and Hospital Epidemiology, 23(12), 740–747. doi: 10.1086/502004
Type
Article
ISSN
0899-823X
Source
http://lps3.www.cambridge.org.proxy.dsmc.or.kr/core/product/identifier/S0195941700080541/type/journal_article
DOI
10.1086/502004
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35869
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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