계명대학교 의학도서관 Repository

Association of promoter region single nucleotide polymorphisms at positions -819C/T and -592C/A of interleukin 10 gene with ischemic heart disease

Metadata Downloads
Author(s)
Gyeong-Im YuHo-Chan ChoYun-Kyeong ChoHyoung-Seob ParkHyuck-Jun YoonHyung-Seop KimChang-Wook NamYoon-Nyun KimKwon-Bae KimEunyoung HaDong-Hoon ShinSeung-Ho Hur
Keimyung Author(s)
Ha, Eun YoungCho, Ho ChanCho, Yun KyeongPark, Hyoung SeobYoon, Hyuck JunKim, Hyung SeopNam, Chang WookKim, Yoon NyunKim, Kwon BaeHur, Seung HoShin, Dong Hoon
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Dept. of Preventive Medicine (예방의학)
Journal Title
Inflammation Research
Issued Date
2012
Volume
61
Issue
8
Abstract
Objective Ischemic heart disease (IHD) is a disease
characterized by ischemia of the heart muscle, usually due
to coronary artery disease. Interleukin-10 (IL10) is a proinflammatory
cytokine known to protect endothelial
function. In this study, we investigated the association of
promoter region polymorphisms of the IL10 gene with
IHD.
Methods Werecruited 313 control and 173 IHDpatients. The
selected SNPs in IL10 were genotyped using pyrosequencing.
Results SNPs at positions -592C/A and -819C/T were
statistically associatedwith IHD (P = 0.014 and P = 0.037).
Similarly, the mean value of C-reactive protein in the C allele
at -592C/A and -819C/T was significantly higher than that
in the A allele at -592C/A (P = 0.026) and T allele at
-819C/T (P = 0.026). The presence of hypertension in the C
allele at -592C/A and -819C/T was significantly more frequent
than that in the A allele at-592C/A (P = 0.044) and T
allele at-819C/T (P = 0.044). In the haplotype of two SNPs
(-592C/A and -819C/T), one haplotype (CC) presented an
association with IHD (P = 0.012).
Conclusions These results indicate that the C allele with
SNPs at position -592C/A and -819C/T of IL10 gene may
be associated with IHD in the Korean population.
Keywords Ischemic heart disease Interleukin-10
Single nucleotide polymorphism
Keimyung Author(s)(Kor)
하은영
조호찬
조윤경
박형섭
윤혁준
김형섭
남창욱
김윤년
김권배
허승호
신동훈
Publisher
School of Medicine
Citation
Gyeong-Im Yu et al. (2012). Association of promoter region single nucleotide polymorphisms
at positions -819C/T and -592C/A of interleukin 10 gene
with ischemic heart disease. Inflammation Research, 61(8), 899–905. doi: 10.1007/s00011-012-0482-2
Type
Article
ISSN
1023-3830
Source
https://link.springer.com/article/10.1007%2Fs00011-012-0482-2
DOI
10.1007/s00011-012-0482-2
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35870
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.