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Association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with overweight/obesity in a Korean population

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Author(s)
Gyeong-Im YuEunyoung HaSung-Hee ParkJae-Hyung ParkHyun-Sook JangJae-Hoon BaeIn-Sung ChungDong-Hoon ShinDae-Kyu Song
Keimyung Author(s)
Chung, In SungShin, Dong HoonHa, Eun YoungPark, Jae HyungBae, Jae HoonSong, Dae Kyu
Department
Dept. of Preventive Medicine (예방의학)
Dept. of Biochemistry (생화학)
Dept. of Physiology (생리학)
Institute for Cancer Research (암연구소)
Institute for Medical Science (의과학연구소)
Journal Title
Inflammation Research
Issued Date
2011
Volume
60
Issue
12
Abstract
Objective Obesity is characterized by the activation of an
inflammatory process leading to an increase in proinflammatory
cytokines and adipokines. This study was designed
to investigate the genetic association between tumor
necrosis factor-a (TNF-a) polymorphisms and the risk of
obesity in the Korean population.
Methods Three single nucleotide polymorphisms [G-238A
(rs361525), C-857T (rs1799724), and C-863A (rs1800630)]
in the promoter region of TNF-a gene were analyzed in 123
control [body mass index (BMI) between 18 and 23] and 208
overweight/obese (BMI C 23) subjects.
Results The mean values of BMI in the control and overweight/
obese groups were 21.1 ± 1.4 and 25.4 ± 1.8,
respectively. Of the three SNPs, G-238A presented a significant
association with overweight/obesity in the
codominant model; the frequency of the G/G genotype in
the overweight/obese group was 9.3%higher than that in the
control group (P = 0.0046). When control and overweight/
obesity subjects were combined together and analyzed, the
level of high-density lipoprotein (HDL) was significantly
higher in the C-857T C/C type SNP (P\0.05).
Conclusions The results of this study suggest that the G
allele of G-238A in TNF-a gene may be a risk factor for
overweight/obesity in the Korean population and that the C
allele of C-857T may be an protective factor in relation to
the HDL level in the general Korean population.
Keywords Body mass index Tumor necrosis factor
Obesity/overweight Polymorphism
Keimyung Author(s)(Kor)
정인성
신동훈
하은영
박재형
배재훈
송대규
Publisher
School of Medicine
Citation
Gyeong-Im Yu et al. (2011). Association of tumor necrosis factor-α (TNF-α) promoter
polymorphisms with overweight/obesity in a Korean population. Inflammation Research, 60(12), 1099–1105. doi: 10.1007/s00011-011-0372-z
Type
Article
ISSN
1023-3830
Source
https://link.springer.com/article/10.1007%2Fs00011-011-0372-z
DOI
10.1007/s00011-011-0372-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35871
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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