Risk factors and treatment outcomes of community-onset bacteraemia caused by
extended-spectrum β-lactamase-producing Escherichia coli
- Author(s)
- Cheol-In Kang; Jae-Hoon Song; Doo Ryeon Chung; Kyong Ran Peck; Kwan Soo Ko; Joon-Sup Yeom; Hyun Kyun Ki; Jun Seong Son; Seung Soon Lee; Yeon-Sook Kim; Sook-In Jung; Shin-Woo Kim; Hyun-Ha Chang; Seong Yeol Ryu; Ki Tae Kwon; Hyuck Lee; Chisook Moon; Sang Yop Shin; KONSID
- Keimyung Author(s)
- Ryu, Seong Yeol
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- International Journal of Antimicrobial Agents
- Issued Date
- 2010
- Volume
- 36
- Issue
- 3
- Abstract
- The purpose of this study was to identify risk factors for extended-spectrum -lactamase (ESBL)-
producing Escherichia coli amongst community-onset bacteraemia and to evaluate treatment outcomes.
From the database of a nationwide surveillance programme for bacteraemia, data from patients with
community-onset E. coli bacteraemia were analysed. Patients with ESBL-producing E. coli bacteraemia
were compared with those with non-ESBL-producing bacteraemia. The overall proportion of ESBLproducers
was 9.5% (82/865) amongst community-onset E. coli bacteraemia cases. Healthcare-associated
infection, underlying liver disease and primary bacteraemia were significant independent factors associated
with ESBL-producing E. coli bacteraemia (P < 0.05). There was a trend toward mortality being
higher in the ESBL group compared with the non-ESBL group (15.0% vs. 7.6%; P = 0.096). ESBL production
was found to be an independent factor associated with mortality after adjusting for confounding variables
(odds ratio = 2.99, 95% confidence interval 1.01–8.84; P = 0.048), along with severe sepsis, higher
Pitt bacteraemia score, primary bacteraemia, pneumonia and underlying liver disease (P < 0.05). ESBLproducing
E. coli is a significant cause of bacteraemia, even in patients with community-onset infections,
predicting higher mortality, particularly in patients with primary bacteraemia, underlying liver disease
or healthcare-associated infection.
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.