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Fever after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction is associated with adverse outcomes

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Author(s)
Hyun-Ok ChoChang-Wook NamHo-Myung LeeHong-Won ShinYun-Kyeong ChoHyuck-Jun YoonHyoung-Seob ParkHyungseop KimIn-Sung ChungSeung-Ho HurYoon-Nyun KimKwon-Bae Kim
Keimyung Author(s)
Nam, Chang WookCho, Yun KyeongYoon, Hyuck JunPark, Hyoung SeobKim, Hyung SeopHur, Seung HoKim, Yoon NyunKim, Kwon BaeChung, In Sung
Department
Dept. of Internal Medicine (내과학)
Dept. of Preventive Medicine (예방의학)
Journal Title
International Journal of Cardiology
Issued Date
2014
Volume
170
Issue
3
Abstract
Background: Fever is a common finding after primary percutaneous coronary intervention (PPCI) in patientswith
ST-segment elevation myocardial infarction (STEMI). However, its prognostic value is not validated yet.
Objectives: This study sought to evaluate the impact of fever after PPCI in STEMI on adverse clinical outcomes.
Methods: Five hundred fourteen consecutive patients who underwent PPCI due to STEMI were enrolled. Body temperature
(BT) was checked every 6 h for 5 days after PPCI. Patients were divided into two groups according to the
highest quartile of peak BT; peak BT ≤ 37.6 °C (control group) and peak BT N 37.6 °C (fever group). Rates of 1-year
major adverse cardiovascular events (MACE; death, myocardial infarction, any revascularization) were compared.
Results:Theprevalenceof fevergroup(peakBT N 37.6 °C)was 24.7% (127/514).White blood cell count, highly sensitive
C-reactive protein and serum cardiac troponin I level were higher in fever group than control group
(12,162 ± 4199/μL vs. 10,614 ± 3773/μL, p b 0.001; 22.9 ± 49.4 mg/L vs. 7.4 ± 2.5 mg/L, p = 0.001,
16.7 ± 36.9 ng/dl vs. 8.70 ± 26.2 ng/dl, p = 0.027, respectively). The frequency of a history of previous myocardial
infarction and left ventricular ejection fraction was lower in fever group (0.0% vs. 4.7%, p = 0.010;47 ± 8%vs.
49 ± 9 %, p = 0.002, respectively). There was no significant difference in angiographic characteristics between 2
groups. 1-year MACE rates were higher in fever group (11.0% vs. 4.7%, p = 0.010). Multivariate analysis revealed
fever (OR 2.358, 95% CI 1.113–4.998, p = 0.025), diabetes mellitus as risk factor (2.227, 1.031–4.812, 0.042), and
left anterior descending artery as infarct related artery (2.443, 1.114–5.361, 0.026) as independent predictors for
1-year MACE.
Conclusions: Fever after PPCI in patients with STEMI is frequently developed and it can predict adverse clinical
outcome.
Keimyung Author(s)(Kor)
남창욱
조윤경
윤혁준
박형섭
김형섭
허승호
김윤년
김권배
정인성
Publisher
School of Medicine
Citation
Hyun-Ok Cho et al. (2014). Fever after primary percutaneous coronary intervention in ST-segment
elevation myocardial infarction is associated with adverse outcomes. International Journal of Cardiology, 170(3), 376–380. doi: 10.1016/j.ijcard.2013.11.017
Type
Article
ISSN
0167-5273
Source
https://www.sciencedirect.com/science/article/pii/S016752731301989X?via%3Dihub
DOI
10.1016/j.ijcard.2013.11.017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35889
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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