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Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation

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Author(s)
Jang-Ho BaeMichael SchwemmerIn-Kyu LeeHee-Ja LeeKi-Rack ParkKi-Young KimEberhard Bassenge
Keimyung Author(s)
Lee, In Kyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Cardiology
Issued Date
2003
Volume
87
Issue
2-3
Abstract
Background: To analyze the effects of postprandial hypertriglyceridemia with or without antioxidant supplementation—on endothelial
function as related to lipid oxidation in healthy young subjects. Methods and results: Ten healthy male subjects (mean age: 26 years) were
examined three times in fasting state (10 hours) following a high-fat meal, a low-fat meal, or a high-fat meal with additional antioxidant
vitamin E (800 IU), respectively. Serum triglycerides significantly increased 2 and 4 hours after eating the high-fat meal with or without
additional vitamin E. Endothelium-dependent, flow-mediated brachial artery vasodilations (FMD; percentage change in diameter) changed
from 13.361.1% to 6.661.1% ( p,0.05), 7.160.6% ( p,0.05), or 13.260.8% at 2, 4, or 6 hours after eating a high-fat meal. However,
there were no changes of FMD observed following either a low-fat meal or a high-fat meal with additional vitamin E. The flow-dependent
vasodilation inversely correlated to postprandial hypertriglyceridemia (r520.54, p,0.05). Serum malondialdehydes (MDA; lipid
oxidation products) did not significantly change following ingestion of any of the 3 types of meal. Conclusions: This study suggests that
postprandial hypertriglyceridemia-induced endothelial dysfunction is not associated with lipid oxidation and that the protective effects of
vitamin E on endothelial function may be due to some alternative, as of yet unknown, mechanism.
 2002 Elsevier Science Ireland Ltd. All rights reserved.
Keywords: Endothelial dysfunction; Hypertriglyceridemia; Lipid oxidation; Antioxidants
Keimyung Author(s)(Kor)
이인규
Publisher
School of Medicine
Citation
Jang-Ho Bae et al. (2003). Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. International Journal of Cardiology, 87(2–3), 259–267. doi: 10.1016/S0167-5273(02)00347-9
Type
Article
ISSN
0167-5273
Source
https://www.sciencedirect.com/science/article/pii/S0167527302003479?via%3Dihub
DOI
10.1016/S0167-5273(02)00347-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35893
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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