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Echogenicity as a surrogate for bioresorbable everolimus-eluting scaffold degradation: analysis at 1-, 3-, 6-, 12- 18, 24-, 30-, 36- and 42-month follow-up in a porcine model

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Author(s)
Carlos M. CamposYuki IshibashiJeroen EggermontShimpei NakataniYun Kyeong ChoJouke DijkstraJohan H. C. ReiberAlexander SheehyJennifer LaneMarika KamberiRichard RapozaLaura PerkinsHector M. Garcia-GarciaYoshinobu OnumaPatrick W. Serruys
Keimyung Author(s)
Cho, Yun Kyeong
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Cardiovascular Imaging
Issued Date
2015
Volume
31
Issue
3
Abstract
The objective of the study is to validate intravascular
quantitative echogenicity as a surrogate for molecular
weight assessment of poly-l-lactide-acid (PLLA) bioresorbable
scaffold (Absorb BVS, Abbott Vascular, Santa Clara,
California).We analyzed at 9 time points (from 1- to 42-month
follow-up) a population of 40 pigs that received 97 Absorb
scaffolds. The treated regions were analyzed by echogenicity
using adventitia as reference, and were categorized as more
(hyperechogenic or upperechogenic) or less bright (hypoechogenic)
than the reference. The volumes of echogenicity
categories were correlated with the measurements of molecularweight
(Mw) by gel permeation chromatography.Scaffold
struts appeared as high echogenic structures. The quantification
of grey level intensity in the scaffold-vessel compartment
had strong correlation with the scaffold Mw: hyperechogenicity
(correlation coefficient = 0.75; P\0.01), upperechogenicity
(correlation coefficient = 0.63; P\0.01) and
hyper ? upperechogenicity (correlation coefficient = 0.78;
P\0.01). In the linear regression, the R2 for high echogenicity
andMwwas 0.57 for the combination of hyper and upper
echogenicity. IVUS high intensity grey level quantification is
correlated to Absorb BVS residual molecular weight and can
be used as a surrogate for themonitoring of the degradation of
semi-crystalline polymers scaffolds.
Keywords Absorb Bioresorbable vascular scaffold
Degradation Echogenicity IVUS Porcine
Keimyung Author(s)(Kor)
조윤경
Publisher
School of Medicine
Citation
Carlos M. Campos et al. (2015). Echogenicity as a surrogate for bioresorbable everolimus-eluting
scaffold degradation: analysis at 1-, 3-, 6-, 12- 18, 24-, 30-, 36-
and 42-month follow-up in a porcine model. International Journal of Cardiovascular Imaging, 31(3), 471–482. doi: 10.1007/s10554-015-0591-4
Type
Article
ISSN
1569-5794
DOI
10.1007/s10554-015-0591-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35896
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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