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Clear Cell Carcinomas of the Ovary: A Multi-Institutional Study of 129 Cases in Korea With Prognostic Significance of Emi1 and Galectin-3

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Author(s)
Kyueng-Whan MinMoon Hyang ParkSung Ran HongHeejung LeeSun Young KwonSook Hee HongHee Jae JooIn Ae ParkHee Jung AnKwang Sun SuhHoon Kyu OhChong Woo YooMi Jin KimHee Kyung ChangSun Young JunHye Kyoung YoonEun Deok ChangDong Won KimInsun KimThe Gynecologic Pathology Study Group of the Korean Society of Pathologists
Keimyung Author(s)
Kwon, Sun Young
Department
Dept. of Pathology (병리학)
Journal Title
International Journal of Gynecological Pathology
Issued Date
2013
Volume
32
Issue
1
Abstract
Accurate diagnosis of ovarian clear cell carcinoma (CCC) is important because of its poor prognosis with chemoresistance and a high recurrent rate. The clinicopathologic characteristics and prognostic significance of the cell cycle regulator [early mitotic inhibitor-1 (Emi1)] and galactoside-binding protein (Galectin-3) were evaluated. Among 155 CCCs from 18 hospitals in Korea between 1995 and 2006, 129 pure CCCs were selected with consensus using immunohistochemical stains for hepatocyte nuclear factor-1[beta], Wilms' tumor protein, and estrogen receptor. The expressions of Emi1, Galectin-3, p53, and Ki-67 labeling index were analyzed with clinicopathologic parameters and the patient’s survival. The mean age of the patients was 49.6 yr; the tumors were bilateral in 10.9%, and the average size was 12 cm. Adenofibromatous component was found in 7%, and endometriosis in 48.1% of the cases. Psammoma body was seen in 16.3%. Disease-free survival and overall survival rates were 78.3% and 79.1%, respectively. The International Federation of Obstetrics and Gynecology (FIGO) stage was the most important prognostic indicator. Emi1 expression (>5%) was seen in 23.3% of CCCs, and associated with high FIGO grades and poor overall survival (P<0.05). High Galectin-3 (>=80%) expression was seen in 59.7% of CCCs, and associated with FIGO stages III and IV, and high Ki-67 labeling index. High Ki-67 labeling index (>=50%) and p53 expression (>=50%) were seen in 27.1% and 18.6% of CCCs, respectively, but there was no clinicopathologic and prognostic significance. On the basis of the fact that the expression of Emi1 in CCC was correlated with a high histologic grade and worse overall survival, target therapy using inhibitors of Emi1 may be tried in the management of CCC patients with Emi1 expression
Keimyung Author(s)(Kor)
권선영
Publisher
School of Medicine
Citation
Kyueng-Whan Min et al. (2013). Clear Cell Carcinomas of the Ovary: A Multi-Institutional
Study of 129 Cases in Korea With Prognostic Significance
of Emi1 and Galectin-3. International Journal of Gynecological Pathology, 32(1), 3–14. doi: 10.1097/PGP.0b013e31825554e9
Type
Article
ISSN
0277-1691
Source
http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=23202783
DOI
10.1097/PGP.0b013e31825554e9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35901
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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