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Microcystic Stromal Tumor of the Ovary With Mutation in Exon 3 of β-catenin: A Case Report

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Author(s)
Yu Na KangChi Heum ChoSun Young Kwon
Keimyung Author(s)
Kang, Yu NaKwon, Sun YoungCho, Chi Heum
Department
Dept. of Pathology (병리학)
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
International Journal of Gynecological Pathology
Issued Date
2015
Volume
34
Issue
2
Abstract
Summary: Microcystic stromal tumor of the ovary is a very rare ovarian tumor with
distinctive microcystic histologic features and a characteristic immunophenotype of
stromal tumor. However, its origin, tumor pathogenesis, and prognosis have not been
well established until now. We report a very unusual case of a microcystic stromal
tumor of the ovary with a mutation in exon 3 of the b-catenin (CTNNB1) gene.
Macroscopically, the fragmented ovarian tumor showed a diffuse solid mass. Microscopically,
the tumor had a pathognomonic histologic pattern of solid and cellular areas
with microcysts and fibrous hyalinized stroma. Immunohistochemical staining with
CD10, vimentin, CD99, and b-catenin showed positive expression. However, a-inhibin
and E-cadherin showed negativity. Mutational analysis revealed a point mutation in
exon 3 of the b-catenin (CTNNB1) gene. Key Words: Microcystic stromal tumor—
Ovary—b-Catenin—Mutation.
Keimyung Author(s)(Kor)
강유나
권선영
조치흠
Publisher
School of Medicine
Citation
Yu Na Kang et al. (2015). Microcystic Stromal Tumor of the Ovary With Mutation
in Exon 3 of β-catenin: A Case Report. International Journal of Gynecological Pathology, 34(2), 121–125. doi: 10.1097/PGP.0000000000000122
Type
Article
ISSN
0277-1691
Source
http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=25675179
DOI
10.1097/PGP.0000000000000122
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35902
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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