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Should Endometrial Clear Cell Carcinoma be Classified as Type Ⅱ Endometrial Carcinoma?

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Author(s)
Hyo Sook BaeHyesun KimSun Young KwonKyu-Rae KimJae Yun SongInsun Kim
Keimyung Author(s)
Kwon, Sun Young
Department
Dept. of Pathology (병리학)
Journal Title
International Journal of Gynecological Pathology
Issued Date
2015
Volume
34
Issue
1
Abstract
Summary: Endometrial clear cell carcinomas (ECCCs) are considered to be Type II
endometrial carcinomas, like uterine serous adenocarcinoma (SCA), and therefore
aggressive clinical management is indicated. However, according to the limited clinical,
immunohistochemical, and molecular data available in the literature, ECCCs show
overlapping features of SCA and endometrioid adenocarcinomas. Therefore, questions
regarding their designation as the Type II carcinomas have been raised. We performed
immunohistochemical staining for hepatocyte nuclear factor-1b and napsin A for the
histologic confirmation of clear cell carcinoma (CCC), and analyzed immunohistochemical
findings for estrogen receptor, progesterone receptor, HER2/neu, p53, p16,
ARID1A, PTEN, DNA mismatch-repair proteins along with other prognostic factors.
We performed DNA sequencing for the K-RAS, BRAF, PIK3CA, and PTEN genes for
16 pure CCCs. No patients with pure CCC experienced recurrent disease or died of the
disease (0/16, 0%). ECCCs had SCA-like features with rare expression of estrogen
receptor/progesterone receptor (18.8%/6.3%) and no K-RAS mutations, intermediate
features regarding expressions of p53 (37.5%) and p16 (25%), and endometrioid
adenocarcinoma-like features regarding losses of PTEN (81.3%), ARID1A (25%) and
mismatch-repair protein (68.8%), expression of microsatellite instability-high (25%),
HER2/neu (12.5%), and PIK3CA mutations (18.8%). Pure ECCC should not be
regarded as Type II carcinoma, because it shares the immunohistochemical and
molecular characteristics of Type I endometrioid adenocarcinoma and Type II SCA.
Key Words: Endometrial carcinoma—Clear cell adenocarcinoma—Endometrioid
adenocarcinoma—Immunohistochemistry—DNA sequencing.
Keimyung Author(s)(Kor)
권선영
Publisher
School of Medicine
Citation
Hyo Sook Bae et al. (2015). Should Endometrial Clear Cell Carcinoma be
Classified as Type Ⅱ Endometrial Carcinoma? International Journal of Gynecological Pathology, 34(1), 74–84. doi: 10.1097/PGP.0000000000000111
Type
Article
ISSN
0277-1691
Source
http://lps3.insights.ovid.com.proxy.dsmc.or.kr/pubmed?pmid=25473756
DOI
10.1097/PGP.0000000000000111
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35903
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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