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Association of interleukin-10 promoter region polymorphisms with risk factors of Atherosclerosis

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Author(s)
G. I. YuS.-E. JunH.-C. ChoK. O. ParkJ.-H. ChungD. H. ShinI. S. Chung
Keimyung Author(s)
Shin, Dong HoonChung, In SungJun, Sang EunCho, Ho Chan
Department
Dept. of Preventive Medicine (예방의학)
Dept. of Nursing (간호학)
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Immunogenetics
Issued Date
2015
Volume
42
Issue
1
Abstract
Summary
Atherosclerosis is considered as an inflammatory dis-
ease, and carotid artery intima-media thickness (IMT)
and carotid plaque are generally used as intermedi-
ated phenotype of atherosclerosis. The aim of this
study was to investigate whether carotid IMT and
plaque are associated with promoter region polymor-
phisms of interleukin 10 (IL-10) gene. We recruited
135 subjects from a rural area of south-eastern part
of South Korea. Three polymorphisms in the pro-
moter region of IL-10 (1082 A/G, 819 T/C and
592 A/C) were genotyped by pyrosequencing. Caro-
tid IMT was measured at common carotid arteries,
and carotid bulbs and cardiovascular risk factors such
as cholesterol, blood pressure, uric acid and homocy-
steine were measured using blood samples. Subjects
with the minor allele (C) of 819 T/C or the minor
allele (C) of 592A/C showed lower values in carotid
IMT than those with major allele homozygote of
each polymorphism (P = 0.018 and P = 0.031,
respectively). Subjects with carotid plaque were signif-
icantly older and showed higher values in carotid
IMT, uric acid and homocysteine than those without
plaque (P < 0.01, respectively). In conclusion, the
promoter region polymorphisms of IL-10 gene associ-
ate with carotid IMT and plaque. Further studies
with larger samples are needed to provide stronger
evidence to justify anti-atheromatous properties of
IL-10.
Keimyung Author(s)(Kor)
신동훈
정인성
전상은
조호찬
Publisher
School of Medicine
Citation
G. I. Yu et al. (2015). Association of interleukin-10 promoter region polymorphisms with risk
factors of Atherosclerosis. International Journal of Immunogenetics, 42(1), 31–37. doi: 10.1111/iji.12156
Type
Article
ISSN
1744-3121
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/iji.12156
DOI
10.1111/iji.12156
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35905
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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