Association of interleukin-10 promoter region polymorphisms with risk
factors of Atherosclerosis
- Affiliated Author(s)
- 신동훈; 정인성; 전상은; 조호찬
- Alternative Author(s)
- Shin, Dong Hoon; Chung, In Sung; Jun, Sang Eun; Cho, Ho Chan
- Journal Title
- International Journal of Immunogenetics
- ISSN
- 1744-3121
- Issued Date
- 2015
- Abstract
- Summary
Atherosclerosis is considered as an inflammatory dis-
ease, and carotid artery intima-media thickness (IMT)
and carotid plaque are generally used as intermedi-
ated phenotype of atherosclerosis. The aim of this
study was to investigate whether carotid IMT and
plaque are associated with promoter region polymor-
phisms of interleukin 10 (IL-10) gene. We recruited
135 subjects from a rural area of south-eastern part
of South Korea. Three polymorphisms in the pro-
moter region of IL-10 (1082 A/G, 819 T/C and
592 A/C) were genotyped by pyrosequencing. Caro-
tid IMT was measured at common carotid arteries,
and carotid bulbs and cardiovascular risk factors such
as cholesterol, blood pressure, uric acid and homocy-
steine were measured using blood samples. Subjects
with the minor allele (C) of 819 T/C or the minor
allele (C) of 592A/C showed lower values in carotid
IMT than those with major allele homozygote of
each polymorphism (P = 0.018 and P = 0.031,
respectively). Subjects with carotid plaque were signif-
icantly older and showed higher values in carotid
IMT, uric acid and homocysteine than those without
plaque (P < 0.01, respectively). In conclusion, the
promoter region polymorphisms of IL-10 gene associ-
ate with carotid IMT and plaque. Further studies
with larger samples are needed to provide stronger
evidence to justify anti-atheromatous properties of
IL-10.
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