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FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells

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Author(s)
JUN SOO PARKWAN TAE KIMSHIN KIMTAEG KYU KWONBYEONG-CHURL JANGEUNG-SEOK LEEJONG WOOK PARK
Keimyung Author(s)
Kim, ShinKwon, Taeg KyuPark, Jong WookJang, Byeong Churl
Department
Dept. of Immunology (면역학)
Dept. of Molecular Medicine (분자의학)
Journal Title
International Journal of Molecular Medicine
Issued Date
2014
Volume
34
Issue
4
Abstract
. The inhibition of topoisomerase can suppress the growth of cancer cells and induce apoptosis. The aim of this study was to evaluate the anticancer effects and mechanisms of action of a novel topoisomerase inhibitor, 4-(furan-2-yl)-2-(pyridin-2-yl)-5,6-dihydro-1,10-phenanthroline (FPDHP). FPDHP suppressed the growth of Caki, A549, HT29 and MDA-MB-231 cells, and induced caspase-dependent apoptosis in the Caki cells. In particular, FPDHP also induced caspase-dependent apoptosis and the downregulation of the protein expression levels of cellular FLICE-like inhibitory protein (cFLIP) and the phosphorylation of Akt in Caki cells. Notably, the overexpression of cFLIP, but not that of Akt, in part, blocked the FPDHP-mediated apoptosis in Caki cells. In addition, FPDHP was further shown to induce the caspase-independent detachment of Caki cells from the culture dish; higher populations of apoptotic cells were observed in the detached cells than in the attached cells. To the best of our knoweledge, these results collectively demonstrate for the first time that FPDHP has a killing effect on Caki cells, which is mediated through both caspase-dependent apoptosis and caspase-independent cell detachment
Keimyung Author(s)(Kor)
김신
권택규
박종욱
장병철
Publisher
School of Medicine
Citation
JUN SOO PARK et al. (2014). FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells. International Journal of Molecular Medicine, 34(4), 1051–1056. doi: 10.3892/ijmm.2014.1875
Type
Article
ISSN
1107-3756
Source
https://www.spandidos-publications.com/ijmm/34/4/1051
DOI
10.3892/ijmm.2014.1875
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35911
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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