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Curcumin induces apoptosis and inhibits prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis

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Author(s)
CHEOL PARKDONG-OH MOONIL-WHAN CHOIBYUNG TAE CHOITAEK-JEONG NAMCHUNG-HO RHUTAEG KYU KWONWON HO LEEGI-YOUNG KIMYUNG HYUN CHOI
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
International Journal of Molecular Medicine
Issued Date
2007
Volume
20
Issue
3
Abstract
. Rheumatoid arthritis (RA) is a chronic inflammatory
disease that is characterized by hyperplasia of the synovial
fibroblasts, which is partly the result of decreased apoptosis.
This study investigated the mechanisms through which
curcumin, a polyphenolic compound from the rhizome of
Curcuma longa, exerts its anti-proliferative action in the
synovial fibroblasts obtained from patients with RA.
Exposure of the synovial fibroblasts to curcumin resulted in
growth inhibition and the induction of apoptosis, as measured
by MTT assay, fluorescent microscopy and Annexin-V-based
assay. RT-PCR and immunoblotting showed that treating the
cells with curcumin resulted in the down-regulation of antiapoptotic
Bcl-2 and the X-linked inhibitor of the apoptosis
protein as well as the up-regulation of pro-apoptotic Bax
expression in a concentration-dependent manner. Curcumininduced
apoptosis was also associated with the proteolytic
activation of caspase-3 and caspase-9, and the concomitant
degradation of poly(ADP-ribose) polymerase protein.
Furthermore, curcumin decreased the expression levels of the
cyclooxygenase (COX)-2 mRNA and protein without
causing significant changes in the COX-1 levels, which was
correlated with the inhibition of prostaglandin E2 synthesis.
These results show that curcumin might help identify a new
therapeutic pathway against hyperplasia of the synovial
fibroblasts in RA.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
CHEOL PARK et al. (2007). Curcumin induces apoptosis and inhibits prostaglandin
E2 production in synovial fibroblasts of patients
with rheumatoid arthritis. International Journal of Molecular Medicine, 20(3), 365–372. doi: 10.3892/ijmm.20.3.365
Type
Article
ISSN
1107-3756
Source
https://www.spandidos-publications.com/ijmm/20/3/365
DOI
10.3892/ijmm.20.3.365
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35922
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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