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RB-resistant Abl kinase induces delayed cell cycle progression and increases susceptibility to apoptosis upon cellular stresses through interaction with p53

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Author(s)
Jae-We ChoJunah ChungWon-Ki BaekSeong-Il SuhTaeg Kyu KwonJong-Wook ParkMin-Ho Suh
Keimyung Author(s)
Cho, Jae WeKwon, Taeg KyuPark, Jong WookBaek, Won KiSuh, Min HoSuh, Seong Il
Department
Dept. of Dermatology (피부과학)
Dept. of Immunology (면역학)
Dept. of Microbiology (미생물학)
Journal Title
International Journal of Oncology
Issued Date
2003
Volume
22
Issue
6
Abstract
c-Abl, a non-receptor tyrosine kinase, is found in both nucleus and cytoplasm of proliferating fibroblasts. RB negatively regulates the kinase activity of c-Abl. Overexpression of kinase active c-Abl can overcome RB-induced growth arrest in Saos-2 cells. However, we previously reported that disruption of the RB matchmaker function leads to delayed cell cycle progression in the presence of p53. In this study, we investigated whether overexpression of mutant c-Abl (AS2, RB-resistant Abl kinase) not only lead to delayed cell cycle progression but also make cells susceptible to apoptosis under coexpression with a fragment of RB C pocket in human skin fibroblast. AS2 expressing cells showed delayed cell growth rate in normal growth condition. After genotoxic stress such as etoposide treatment, AS2 expressing cells readily progressed into apoptosis through p53 and caspase-3 activations. Our results suggest that expression of AS2 not only induces delayed cell cycle progression but also results in increased sensitivity to apoptosis in the presence of p53.
Keimyung Author(s)(Kor)
조재위
권택규
박종욱
백원기
서민호
서성일
Publisher
School of Medicine
Citation
Jae-We Cho et al. (2003). RB-resistant Abl kinase induces delayed cell cycle progression and increases susceptibility to apoptosis upon cellular stresses through interaction with p53. International Journal of Oncology, 22(6), 1193–1199. doi: 10.3892/ijo.22.6.1193
Type
Article
ISSN
1019-6439
Source
https://www.spandidos-publications.com/ijo/22/6/1193
DOI
10.3892/ijo.22.6.1193
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35932
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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