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Clinical characteristics and outcomes of H1N1-associated pneumonia among adults in South Korea

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Author(s)
W-I. ChoiJ-J. YimJ. ParkS-C. KimM. J. NaW-Y. LeeS-B. HongH. S. ChoiS. H. JangW. J. KimK. JeonJ. H. KimJ. C. ChoiC-H. LeeC. H. KimJ. Y. Kim
Keimyung Author(s)
Choi, Won Il
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Tuberculosis and Lung Disease
Issued Date
2011
Volume
15
Issue
2
Abstract
BACKGROUND: Pneumonia has been reported to be the
most life-threatening complication of infl uenza virus
infection.
OBJECTIVE: To describe clinical characteristics and determine
risk factors for death among patients with H1N1-
associated pneumonia.
DESIGN: A retrospective cohort study included all adult
patients diagnosed and treated with H1N1-associated
pneumonia in 14 participating institutions between
1 May 2009 and 28 February 2010 in South Korea. Clinical
outcomes were summarised and predictors for death
evaluated through univariate and multivariate analysis.
RESULTS: A total of 269 adult patients with H1N1-
a ssociated pneumonia were diagnosed and treated. Hospital
visits or admissions peaked in November 2009, coinciding
with the peak in the 2009 H1N1 epidemic in
South Korea. The patients’ median age was 48 years;
143 were male. Most (n = 266, 98.9%) were admitted
for treatment: 97 (36.1%) required intensive care and
28 (10.4%) needed mechanical ventilation. Despite the
use of antiviral and antibacterial agents, 19 patients
(7.1%) died. Risk factors predictive of death included
presence of malignancy (aOR 12.0, 95%CI 2.8–51.5),
and pneumonia severity index (PSI) score (aOR 1.03,
95%CI 1.01–1.04).
CONCLUSION: Deaths among adult patients with
H1N1-associated pneumonia were not rare. Clinicians
should be aware of the possibility of a poor prognosis
among H1N1-associated pneumonia patients with underlying
malignancy or high PSI score.
KEY WORDS: H1N1 infl uenza; pneumonia; outcome
Keimyung Author(s)(Kor)
최원일
Publisher
School of Medicine
Citation
W-I. Choi et al. (2011). Clinical characteristics and outcomes of H1N1-associated
pneumonia among adults in South Korea. International Journal of Tuberculosis and Lung Disease, 15(2), 270–275.
Type
Article
ISSN
1027-3719
Source
http://www.ingentaconnect.com/content/iuatld/ijtld/2011/00000015/00000002/art00023;jsessionid=22s37wvb636fv.x-ic-live-03
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35940
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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