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Pleural cancer antigen-125 levels in benign and malignant pleural effusions

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Author(s)
W-I. ChoiD. QamaM. Y. LeeK. Y. Kwon
Keimyung Author(s)
Choi, Won IlKwon, Kun YoungLee, Mi Young
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Dept. of Preventive Medicine (예방의학)
Journal Title
International Journal of Tuberculosis and Lung Disease
Issued Date
2013
Volume
17
Issue
5
Abstract
OBJECTIVE: To examine the properties of mesothelial
cells by measuring pleural cancer antigen 125 (CA-125)
levels in different types of benign and malignant pleural
effusions.
DESIGN: In this retrospective study, pleural fluid was
collected from 326 patients; pleural CA-125 levels were
measured using radioimmunoassay. Patients were classified
into five groups according to the aetiology of pleural
effusions: I) tuberculosis, II) malignant, III) pyogenic,
IV) congestive heart failure, and V) hepatic hydrothorax.
RESULTS: CA-125 levels were significantly higher in the
malignant group than in all benign groups. There was
no difference in pleural CA-125 levels between transudate
and exudate benign aetiologies. Although pleural
CA-125 levels were significantly higher in malignant
than benign effusions, about one third of malignant pleural
effusions had levels of <600 U/ml. Among malignancies,
there were no significant differences in pleural
CA-125 levels between histological types.
CONCLUSION: CA-125 levels in benign pleural effusions
may not be influenced by pleural inflammation or
hydrostatic or oncotic pressure changes. Pleural CA-125
levels may not be influenced by the histological type of
tumour in malignant pleural effusions, suggesting that
mesothelial cell properties may not be altered by these
factors in the pleural space.
KEY WORDS: CA-125; cell property; mesothelium
Keimyung Author(s)(Kor)
최원일
권건영
이미영
Publisher
School of Medicine
Citation
W-I. Choi et al. (2013). Pleural cancer antigen-125 levels in benign and malignant
pleural effusions. International Journal of Tuberculosis and Lung Disease, 17(5), 693–697. doi: 10.5588/ijtld.12.0635
Type
Article
ISSN
1027-3719
Source
http://www.ingentaconnect.com/content/iuatld/ijtld/2013/00000017/00000005/art00023
DOI
10.5588/ijtld.12.0635
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35942
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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