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Increased glycodelin levels in gynecological malignancies

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Author(s)
I. R. HOROWITZC. CHOM. SONGL. C. FLOWERSN. SANTANAMS. PARTHASARATHYS. RAMACHANDRAN
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
International Journal of Gynecological Cancer
Issued Date
2001
Volume
11
Issue
3
Abstract
. Horowitz IR , Cho C, Song M, Flowers LC, Santanam N,
Parthasarathy S, Ramachandran S. Increased glycodelin levels in gynecological
malignancies. Int J Gynecol Cancer 2001;11:173–179.
Glycodelin, an immunosuppressive protein with contraceptive properties,
is synthesized by a variety of tissues and cell types. The ability of
reproductive tissues to synthesize glycodelin is of major interest in pregnancy
and disease conditions. We studied glycodelin levels in subjects
with malignant gynecological tumors and in control subjects. Using a
polyclonal glycodelin antibody against the synthetic glycodelin peptide
sequence, an enzyme-linked immunosorbent assay (ELISA) was devised
to measure plasma glycodelin levels. The assay detected as much as 5
ng/ml of glycodelin. There was a significant increase in plasma glycodelin
levels in endometrial > ovarian > cervical cancer subjects when compared
to those of controls. Strong expression of mRNA and protein were
found in the ovarian and endometrial tumor tissues. Given glycodelin’s
immunosuppressive abilities, increased level of glycodelin may facilitate
tumor growth in gynecological malignancies.
KEYWORDS: glycodelin, immunosuppression, tumor.
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
I. R. HOROWITZ et al. (2001). Increased glycodelin levels in
gynecological malignancies. International Journal of Gynecological Cancer, 11(3), 173–179. doi: 10.1046/j.1525-1438.2001.01017.x
Type
Article
ISSN
1048-891X
Source
https://insights.ovid.com/pubmed?pmid=11437921
DOI
10.1046/j.1525-1438.2001.01017.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35946
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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