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Lymph Node Status Did Not Significantly Improve the Predictability of Survival in Patients With Clinically Early-Stage Endometrial Cancer

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Author(s)
Hyo Sook BaeJong-Min LeeJae-Kwan LeeJae-Weon KimChi-Heum ChoSeok-Mo KimSang-Yoon ParkChan-Yong ParkKi-Tae KimSokbom Kang
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
International Journal of Gynecological Cancer
Issued Date
2014
Volume
24
Issue
8
Abstract
Objective: The aim of this study was to determine whether knowledge of lymph node
status improves survival prediction in clinically early-stage endometrial cancer.
Methods: The records of 661 patients with apparently uterine-confined disease were
reviewed. The performance in predicting overall survival and cause-specific survival was
compared between a multivariate prognostic model with nodal status and a model without
nodal status by calculating Harrell concordance index.
Results: Among 661 patients with clinically early-stage endometrial cancer, the lymph
node metastasis rate was 8.3% (55/661). Lymph node metastasis independently associated
with cause-specific survival only when no stratification according to adjuvant treatment was
applied (P = 0.035). After stratification according to adjuvant radiotherapy, lymph node
status marginally associated with cause-specific survival (P = 0.073), whereas myometrial
invasion retained its strong association with cause-specific survival (P G 0.001). However,
there was no significant difference in the performance of the survival model using only
uterine factors and the model using lymph node status and uterine factors (concordance
index, 0.77 vs 0.77, respectively; P = 0.798).
Conclusions: Knowledge of lymph node status did not significantly improve the performance
of survival prediction in apparently uterine-confined endometrial cancer, although it
was independently associated with survival. In the patients with clinically early-stage endometrial
cancer, the accuracy of the prediction of survival was comparable between risk
grouping without lymph node status and that including lymph node status.
Key Words: Endometrial cancer, Lymph node metastasis, Risk factor, Survival
Received May 20, 2014, and in revised form July 13, 2014.
Accepted for publication July 13, 2014.
(Int J Gynecol Cancer 2014;24: 1449Y1454)
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
Hyo Sook Bae et al. (2014). Lymph Node Status Did Not Significantly Improve the
Predictability of Survival in Patients With Clinically
Early-Stage Endometrial Cancer. International Journal of Gynecological Cancer, 24(8), 1449–1454. doi: 10.1097/IGC.0000000000000237
Type
Article
ISSN
1048-891X
Source
https://ovidsp.tx.ovid.com/sp-3.30.0b/ovidweb.cgi?QS2=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
DOI
10.1097/IGC.0000000000000237
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35983
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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