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Inhibitory effect of butein on tumor necrosis factor-α-induced expression of cell adhesion molecules in human lung epithelial cells via inhibition of reactive oxygen species generation, NF-κB activation and Akt phosphorylation

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Author(s)
JI HOON JANGEUN SUN YANGKYOUNG-JIN MINTAEG KYU KWON
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
International Journal of Molecular Medicine
Issued Date
2012
Volume
30
Issue
6
Abstract
. Cell adhesion molecules play an important role in inflammatory response, angiogenesis and tumor progression. Butein (tetrahydroxychalcone) is a small molecule from natural sources, known to be a potential therapeutic drug with anti-inflammatory, anticancer and antioxidant activities. In the present study, we investigated the inhibitory effect of butein on tumor necrosis factor (TNF)-α-induced adhesion molecule expression and its molecular mechanism of action. Butein significantly decreased TNF-α-induced monocyte (U937) cell adhesion to lung epithelial cells in a dose-dependent manner. Butein also inhibited the protein and mRNA expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in TNF-α-stimulated A549 human lung epithelial cells in a dose-dependent manner. Butein inhibited TNF-α-induced reactive oxygen species (ROS) generation and nuclear factor-κB (NF-κB) activation in A549 cells; it also inhibited the phosphorylation of MAPKs and Akt, suggesting that the MAPK/Akt signaling pathway may be involved in the butein-mediated inhibition of TNF-α-induced leukocyte adhesion to A549 cells. Collectively, our results suggest that butein affects cell adhesion through the inhibition of TNF-α-induced ICAM-1 and VCAM-1 expression by inhibiting the NF-κB/MAPK/Akt signaling pathway and ROS generation, thereby, elucidating the role of butein in the anti-inflammatory response.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
JI HOON JANG et al. (2012). Inhibitory effect of butein on tumor necrosis factor-α-induced expression of cell adhesion molecules in human lung epithelial
cells via inhibition of reactive oxygen species generation, NF-κB activation and Akt phosphorylation. International Journal of Molecular Medicine, 30(6), 1357–1364. doi: 10.3892/ijmm.2012.1158
Type
Article
ISSN
1107-3756
Source
https://www.spandidos-publications.com/ijmm/30/6/1357
DOI
10.3892/ijmm.2012.1158
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35988
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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