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Roles of SEA-expressing Staphylococcus aureus, isolated from an atopic dermatitis patient, on expressions of human ß-defensin-2 and inflammatory cytokines in HaCaT cells

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Author(s)
JAE-WE CHOSUN-YOUNG CHOKYU-SUK LEE
Keimyung Author(s)
Cho, Jae WeLee, Kyu Suk
Department
Dept. of Dermatology (피부과학)
Journal Title
International Journal of Molecular Medicine
Issued Date
2009
Volume
23
Issue
3
Abstract
. Atopic dermatitis (AD) shows an increased
susceptibility to Staphylococcus aureus infection partly due
to decreased expression of human ß-defensin-2 (HBD-2).
Interestingly, it was reported that the nasal carrier S. aureus
down-regulates the expression of HBD-2 and -3, thereby the
carrier strains of S. aureus retain an advantage to epithelial
colonization and infection. In this study, we tried to isolate and
characterize S. aureus from an AD patient, with recurrent
oozing on his face. We studied the increased expression of
inflammatory cytokines, such as IL-1ß, -6, -8, and TNF-· in
S. aureus treated-HaCaT cells, which are mediated by secreting
superantigens (SAgs), structural component, or both. In addition,
we investigated whether the SAgs from S. aureus can downregulate
the expression of HBD-2 in HaCaT cells making
favorable conditions for colonization on skin. Our data showed
that the isolated S. aureus has the exotoxin gene, sea exotoxin.
The SEA producing-S. aureus induced the expression of IL-1ß,
-6, -8 cytokines, and TNF-· in HaCaT cells. The expression of
HBD-2 was increased in S. aureus-treated HaCaT cells.
Furthermore IL-8 was also induced by the structure component
of S. aureus. Taken together, the SEA producing S. aureus
induced the up-regulation of pro-inflammatory cytokines as
well as HBD-2, thereby resulting in induction of the persistent
eczematous skin lesions in AD. Thus, our data may give
insight into understanding the pathogenesis by which S.
aureus induces and aggravates eczematous skin lesions in AD.
Keimyung Author(s)(Kor)
조재위
이규석
Publisher
School of Medicine
Citation
JAE-WE CHO et al. (2009). Roles of SEA-expressing Staphylococcus aureus, isolated from an
atopic dermatitis patient, on expressions of human ß-defensin-2
and inflammatory cytokines in HaCaT cells. International Journal of Molecular Medicine, 23(3), 331–335. doi: 10.3892/ijmm_00000135
Type
Article
ISSN
1107-3756
Source
https://www.spandidos-publications.com/ijmm/23/3/331
DOI
10.3892/ijmm_00000135
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35990
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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