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Morin, a Flavonoid from Moraceae, Induces Apoptosis by Induction of BAD Protein in Human Leukemic Cells

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Author(s)
Cheol ParkWon Sup LeeSe-Il GoArulkumar NagappanMin Ho HanSu Hyun HongGon Sup KimGi Young KimTaeg Kyu KwonChung Ho RyuSung Chul ShinYung Hyun Choi
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
International Journal of Molecular Sciences
Issued Date
2015
Volume
16
Issue
1
Abstract
Evidence suggests that phytochemicals can safely modulate cancer cell biology
and induce apoptosis. Here, we investigated the anti-cancer activity of morin, a flavone
originally isolated from members of the Moraceae family in human leukemic cells,
focusing on apoptosis. An anti-cancer effect of morin was screened with several
human leukemic cell lines. U937 cells were most sensitive to morin, where it induced
caspase-dependent apoptosis in a dose-dependent manner. It also induced loss of MMP
(ΔΨm) along with cytochrome c release, down-regulated Bcl-2 protein, and up-regulated
BAX proteins. The apoptotic activity of morin was significantly attenuated by Bcl-2
augmentation. In conclusion, morin induced caspase-dependent apoptosis through an
intrinsic pathway by upregulating BAD proteins. In addition, Bcl-2 protein expression is
also important in morin-induced apoptosis of U937 cells. This study provides evidence that
morin might have anticancer properties in human leukemic cells.
Keywords: morin; apoptosis; BAD; Bcl-xL; leukemia
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Cheol Park et al. (2015). Morin, a Flavonoid from Moraceae, Induces Apoptosis by
Induction of BAD Protein in Human Leukemic Cells. International Journal of Molecular Sciences, 16(1), 645–659. doi: 10.3390/ijms16010645
Type
Article
ISSN
1661-6596
DOI
10.3390/ijms16010645
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35996
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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