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Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt

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Author(s)
GONSUP KIMJIN MYUNG JUNGCHUNG HO RYUGI-YOUNG KIMHYE JIN HWANGTAEG KYU KWONYUNG HYUN CHOIMIN HO HANWON SUP LEEJING NAN LU
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
International Journal of Oncology
Issued Date
2012
Volume
40
Issue
6
Abstract
. Citrus fruits have been used as edible fruits and
a traditional medicine since ancient times. In particular, the
peels of immature citrus fruits are frequently prescribed in
concert with other support herbs for many types of disease
including cancer. We investigated the anti-proliferative
activity of the peels of Citrus aurantium L. along with their
effects on apoptosis. We prepared crude methanol extracts
of the peels of Citrus aurantium L. (CMEs) and performed
experiments using U937 human leukemia cells. The growth
of U937 cells was inhibited by CME treatment in a dosedependent
manner, and CME induced caspase-dependent
apoptosis. CME inhibited the expression of XIAP and
Bcl-xL which are anti-apoptotic proteins. CME inhibited Akt
activity in a dose-dependent manner. The apoptotic activity
of CME was significantly attenuated by Akt augmentation.
In conclusion, this study suggested that CME should induce
caspase-dependent apoptosis at least in part through Akt
inhibition, providing evidence that CMEs have anticancer
activity on human leukemia cells.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
GONSUP KIM et al. (2012). Citrus aurantium L. exhibits apoptotic effects on U937
human leukemia cells partly through inhibition of Akt. International Journal of Oncology, 40(6), 2090–2096. doi: 10.3892/ijo.2012.1350
Type
Article
ISSN
1019-6439
Source
http://www.spandidos-publications.com/ijo/40/6/2090
DOI
10.3892/ijo.2012.1350
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36002
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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