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Old Age at Diagnosis Is Associated With Favorable Outcomes in Korean Patients With Inflammatory Bowel Disease

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Author(s)
Jae Hyuk ChoiEun Soo KimKwang Bum ChoKyung Sik ParkYoo Jin LeeSang Min LeeYu Jin KangByung Ik JangKyeong Ok KimDaegu-Gyeongbuk Gastrointestinal Study Group (DGSG)
Keimyung Author(s)
Kim, Eun SooCho, Kwang BumPark, Kyung SikLee, Yoo Jin
Department
Dept. of Internal Medicine (내과학)
Journal Title
Intestinal Research
Issued Date
2015
Volume
13
Issue
1
Abstract
Background/Aims: Despite the rising incidence and prevalence of inflammatory bowel disease (IBD) in Asian populations,
data regarding clinical characteristics of patients in Asia based on age at diagnosis are relatively sparse. The aim of this study
was to compare clinical characteristics based on the age at diagnosis according to the Montreal Classification in Korean IBD
patients. Methods: We recruited consecutive patients with IBD at two tertiary hospitals and retrospectively reviewed their
medical information. Patients were divided into three groups according to their age at diagnosis: youth (<17 years), young adult
(17−40 years), and middle-old (>40 years). The main clinical characteristics for comparison were the achievement of a remission
state at the last follow-up visit, cumulative rate of surgery, and cumulative use of immunomodulators and tumor necrosis
factor-α (TNFα) blockers during the follow-up period. Results: In total, 346 IBD patients were included (Crohn’s disease [CD]
146 and ulcerative colitis 200; 36 youth, 202 young adult, and 113 middle-old). The middle-old group with CD was characterized
by a predominance of uncomplicated behavior (P =0.013) and a lower frequency of perianal disease (P =0.009). The middle-
old group was associated more with a less aggressive disease course than the younger group, as shown by more frequent
remission (P =0.004), being less likely to undergo surgery (P <0.001), and lower cumulative use of immunomodulators and
TNFα blockers (P <0.001). Conclusions: Age at diagnosis according to the Montreal Classification is an important prognostic
factor for Korean IBD patients. (Intest Res 2015;13:60-67)
Key Words: Inflammatory bowel diseases; Age of onset; Prognosis; Crohn disease; Colitis, ulcerative
Keimyung Author(s)(Kor)
김은수
조광범
박경식
이유진
Publisher
School of Medicine
Citation
Jae Hyuk Choi et al. (2015). Old Age at Diagnosis Is Associated With Favorable
Outcomes in Korean Patients With Inflammatory Bowel
Disease. Intestinal Research, 13(1), 60–67. doi: 10.5217/ir.2015.13.1.60
Type
Article
ISSN
1598-9100
DOI
10.5217/ir.2015.13.1.60
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36026
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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