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Response to antidepressants in major depressive disorder with melancholic features: the CRESCEND study

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Author(s)
Su-Jin YangRobert StewartHee-Ju KangSeon-Young KimKyung-Yeol BaeJae-Min KimSung-Won JungMin-Soo LeeHyeon-Woo YimTae-Youn Jun
Keimyung Author(s)
Jung, Sung Won
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Journal of Affective Disorders
Issued Date
2013
Volume
144
Issue
1-2
Abstract
Background: This studyaimedtodeterminewhethermajordepressivedisorderswithmelancholicand
withoutmelancholicfeaturesdifferwithrespecttotheirresponsestotreatmentwithantidepressants.
Methods: From anationwidesampleof18hospitalsinSouthKorea,559presentingpatientswithmajor
depressivedisorderwererecruited.TheDSM-IVbasedStructuredClinicalInterviewwasadministered
for confirmatorydiagnosesanddepressionsubtypeswith/withoutmelancholicfeatures.Afterbaseline
evaluation,theyreceivednaturalisticclinician-determinedantidepressantinterventions.Assessment
scales forevaluatingdepression(HAMD),anxiety(HAMA),globalseverity(CGI-s),andfunctioning
(SOFAS)wereadministeredatbaselineandre-evaluatedat1,2,4,8,and12weekslater.
Results: At baseline,the243(43.5%)participantswithmelancholicfeaturesweremorelikelytohavea
previoushistoryofdepression,andhadhigherHAMAandlowerSOFASscores.Afteradjustmentfor
baselinestatus,participantswithmelancholicfeaturesweremorelikelytoachieveandtoexperience
shortertimestoCGI-sremissionandassociatedwithanenhancedglobalsymptomaticremissionwith
any antidepressanttreatment.TheyweremorelikelytoachieveandtoexperienceshortertimestoCGI-
s remissionandthisdifferencewasstrongestinthosereceivingselectiveserotoninreuptakeinhibitor
(SSRI) antidepressantstreatment.
Limitations: The studywasobservational,andthetreatmentmodalitywasnaturalistic.
Conclusions: These findingssuggestafasterandmoreevidentglobalresponsetopharmacotherapyin
melancholiacomparedtootherdepressivesyndromes,particularlywhereSSRIagentsareused.
Keimyung Author(s)(Kor)
정성원
Publisher
School of Medicine
Citation
Su-Jin Yang et al. (2013). Response to antidepressants in major depressive disorder with
melancholic features: the CRESCEND study. Journal of Affective Disorders, 144(1–2), 42–50. doi: 10.1016/j.jad.2012.06.004
Type
Article
ISSN
0165-0327
Source
https://www.sciencedirect.com/science/article/pii/S0165032712004442?via%3Dihub
DOI
10.1016/j.jad.2012.06.004
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36034
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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