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Comparison of Ezetimibe/Simvastatin 10/20 mg Versus Atorvastatin 20 mg in Achieving a Target Low Density Lipoprotein-Cholesterol Goal for Patients With Very High Risk

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Author(s)
Yun-Kyeong ChoSeung-Ho HurChun-Duk HanHyoung-Seob ParkHyuck-Jun YoonHyungseop KimChang-Wook NamYoon-Nyun KimKwon-Bae KimNam-Hee ParkHee-Jun Park
Keimyung Author(s)
Cho, Yun KyeongHur, Seung HoPark, Hyoung SeobYoon, Hyuck JunKim, Hyung SeopNam, Chang WookKim, Yoon NyunKim, Kwon BaePark, Nam HeePark, Hee Jun
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Dept. of Biomedical Engineering (의용공학과)
Dept. of Internal Medicine (내과학)
Journal Title
Korean Circulation Journal
Issued Date
2011
Volume
41
Issue
3
Keyword
EzetimibeSimvastatinAtorvastatin
Abstract
Background and Objectives: Although recent lipid-lowering therapies are effective in reducing low density lipoprotein-cholesterol (LDL-C) levels, many patients treated with lipid-lowering agents do not achieve target LDL-C levels, especially in very high risk patients. The aim of this study is to compare the effect of ezetimibe/simvastatin 10/20 mg and atorvastatin 20 mg on achieving a target LDL-C goal in very high risk patients. Subjects and Methods: A total of 74 patients with very high risk were enrolled in the study. Very high risk patients were defined as patients that displayed established cardiovascular disease with multiple major risk factors, poorly controlled risk factors, multiple risk factors of the metabolic syndrome and acute coronary syndromes. Patients were randomized into two groups: ezetimibe/simvastatin 10/20 mg (n=36) and atorvastatin 20 mg (n=38). Follow-up lipid profile was obtained 6 weeks later. A target goal of LDL-C was defined as less than 70 mg/dL at follow-up. Results: Baseline clinical and laboratory data were similar between the two groups. Achieving a target LDL-C goal was observed in 41.7% of Group 1 and 44.7% of Group 2 at 6 weeks (p=0.82). Changes in other lipid profiles were not significantly different but the tolerability of the two groups was similar. Conclusion: Ezetimibe/simvastatin 10/20 mg and atorvastatin 20 mg showed similar effects in achieving target LDL-C levels in patients with very high risk.
Keimyung Author(s)(Kor)
조윤경
허승호
박형섭
윤혁준
김형섭
남창욱
김윤년
김권배
박남희
박희준
Publisher
School of Medicine
Citation
Yun-Kyeong Cho et al. (2011). Comparison of Ezetimibe/Simvastatin 10/20 mg Versus Atorvastatin 20 mg in Achieving a Target Low Density Lipoprotein-Cholesterol Goal for Patients With Very High Risk. Korean Circulation Journal, 41(3), 149–153. doi: 10.4070/kcj.2011.41.3.149
Type
Article
ISSN
1738-5520
DOI
10.4070/kcj.2011.41.3.149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36046
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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